1 Endocrinology and Diabetology Department CHU Agadir Morocco.
2 Service d'Endocrinologie diabétologie et maladies métabolique Hôpital Militaire d'instruction Mohammed V de Rabat. Mohamed V University, Rabat.
Case Study
World Journal of Advanced Research and Reviews, 2024, 23(03), 2666–2670
Received on 30 July 2024; revised on 24 September 2024; accepted on 26 September 2024
Mc Cune Albright syndrome is a rare, sporadic disorder manifested by the triad of fibrous bone dysplasia (FD), café-au-lait skin spots and precocious puberty (PP), which may be associated with other hormonal hyperfunctions. The broad spectrum of manifestations reflects the mosaicism of the activating somatic mutation of the GNAS gene in different tissues.
Follow-up of patients with Mc Cune Albright syndrome in adulthood remains essential, and requires multidisciplinary management, as this population remains susceptible to sometimes serious complications related to the hyper-secretory nature of all possible endocrine conditions. We report the case of a 15-year-old female patient with complete Mc Cune Albright syndrome since the age of 9 months.
McCune-Albright syndrome; Fibrous dysplasia; Café-au-lait spots; Precocious puberty; Endocrine hyperfunction; Patient follow-up
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Loubna LOUDAY, Mustapha ASFOUR, Mamadou TOGO, Abderahmane TADLAOUI, Jad ISSOUANI and Ahmed Anas GUEBOUB. Long-Term Clinical Evolution of McCune-Albright syndrome: 15 years of follow-up. World Journal of Advanced Research and Reviews, 2024, 23(3), 2666-2670. Article DOI: https://doi.org/10.30574/wjarr.2024.23.3.2915