Local Application of 35 kDa hyaluronic acid fragment gel–soaked cotton balls in patients with tooth and gingival pain and swelling: A case series

Dental procedures such as tooth restoration, tooth transplantation, tooth extraction, scaling, and local anesthetic injection frequently induce acute tooth and gingival pain, often accompanied by inflammatory manifestations including gingival swelling. These postoperative symptoms can negatively affect patients’ oral comfort and overall quality of life. In this case series, a 0–10 numeric rating scale (NRS) was used to evaluate the clinical effects of locally applying cotton balls soaked in 10% high-concentration 35 kDa hyaluronic acid fragment (HA35) gel in nine patients experiencing maxillofacial pain and gingival swelling following dental procedures. The results suggested that this intervention may help relieve tooth and gingival pain associated with dental procedures and may contribute to the reduction of gingival swelling. The treatment exhibited both rapid analgesic activity and clear anti-inflammatory effects, suggesting promising clinical value for the immediate management of postoperative oral symptoms.