Plasma levels of obestatin and ghrelin and obestatin/ghrelin ratio in obese patients
1 Laboratory of Biochemistry and Biotechnology LR01ES05, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia.
2 Higher School of Health Sciences and Technics, University of Tunis El Manar, Tunis, Tunisia.
3 Department of Endocrinology, Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Research Article
World Journal of Advanced Research and Reviews, 2022, 14(01), 336–341
Article DOI: 10.30574/wjarr.2022.14.1.0320
Publication history:
Received on 08 March 2022; revised on 14 April 2022; accepted on 16 April 2022
Abstract:
Background: Obestatin and ghrelin are two gastric hormones that have a potential role in dietary intake regulation. Obestatin/ghrelin ratio has been proposed as activity markers in obesity. The study aimed to evaluate ghrelin, obestatin and the ghrelin/obestatin ratio in obese compared to control subjects and to determine their relationship with anthropometric and metabolic parameters.
Methods: Fasting obestatin and ghrelin levels were measured using enzyme-linked immunosorbent assay ELISA in 28 obese and 24 healthy subjects. The fasting ghrelin/obestatin ratio was calculated. Anthropometric and metabolic parameters were also assessed.
Results: Obese patients had significantly lower obestatin and ghrelin blood levels compared with controls. The Ghrelin/Obestatin ratio was significantly lower in obese group 0.813±0.0417 ng/ml than in the control group 0.896±0.049 ng/ml, (p<0.001). In obese patients, obestatin and ghrelin were significantly and negatively correlated with BMI and positively correlated with HDL-C.
Conclusion: Circulating preprandial ghrelin to obestatin ratio is decreased obese subjects. We suggest that low preprandial ghrelin to obestatin ratio may be involved in the etiology and pathophysiology of obesity.
Keywords:
Obesity; Ghrelin; Obestatin; BMI and Lipid Parameters
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