Biochemical changes associated with H. pylori infection in humans
1 Department of biochemistry, school of biological sciences, federal university of technology, Owerri Imo State, Nigeria.
2 British Columbia institute of technology, Burnaby, B.C, Canada.
Research Article
World Journal of Advanced Research and Reviews, 2024, 22(01), 1546–1556
Article DOI: 10.30574/wjarr.2024.22.1.1224
Publication history:
Received on 12 March 2024; revised on 20 April 2024; accepted on 22 April 2024
Abstract:
Since its first isolation, H. pylori, a Gram-negative flagellated bacterium, has been the subject of intensive research because of its widespread dissemination and associations with several disorders. The bacterium is proven to be a causative factor for a number of gastric diseases, such as gastritis, gastric adenocarcinoma, and MALT-lymphoma. While H. pylori infection has been reported to be linked to several extra-gastric diseases, this study investigated extra-gastric manifestation of H. pylori using specific biomarkers in humans. The GERDs questionnaire was used to randomly chose 150 (one hundred and fifty) participants, of which 75 (seventy five) were found to be H. pylori positive and another 75 (seventy five) were chosen as negative controls. Samples were gathered, and biochemical characteristics were examined. The study revealed a significant (p<0.05) reduction in the levels of oxidative stress markers, glutathione peroxidase (GPX), vitamin C (vit C) and no significant difference was observed in malondialdehyde (MDA) and Total iron concentrations, although with a mean increase and reduction respectively. For the lipid profile biomarker results were statistically (p<0.05) significant for triglyceride (TG) and low density lipoprotein(LDLc) while no significant difference was observed in total cholesterol (TC) and high density lipoprotein (HDLc). Kidney function assessment revealed a statistical (p > 0.05) no significant different with sodium (Na+), potassium (K+), chloride (Cl-) and bicarbonate (HCO2-) concentrations while there was a significant difference in urea and creatinine concentrations when compared with the control subjects. In the liver function parameters, a statistical (p<0.05) significant difference was observed with the aminotransferases (ALT, AST, ALP) and conjugated bilirubin while total bilirubin had a no significant difference when compared with the control subjects. A correlation coefficient analysis of parameter in H. pylori positive subjects were significantly adjusted (p<0.05) for TG, total cholesterol, aminotransferases and bilirubin. The aim of the study was to investigate the biochemical changes of H. pylori infection in humans using specific biomarkers.
Keywords:
H. pylori; Mucosa associated lymphoid tissue; Gastro-esophageal reflux disease.
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