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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in April 2026 (Volume 30, Issue 1) Submit manuscript

Asthma, COPD, the "asthma-COPD" syndrome and severe asthma - relatives or "incidental strangers"?

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  • Asthma, COPD, the "asthma-COPD" syndrome and severe asthma - relatives or "incidental strangers"?

Plamen Todorov Titorenkov * and Milena Dimitrova Encheva

Clinic for Pulmonary Diseases, Military Medical Academy, Sofia, Bulgaria.
 
Review Article
World Journal of Advanced Research and Reviews, 2024, 24(03), 1354-1363
Article DOI: 10.30574/wjarr.2024.24.3.3828
DOI url: https://doi.org/10.30574/wjarr.2024.24.3.3828
 
Received on 05 November 2024; revised on 12 December 2024; accepted on 14 December 2024
 
Objective: Airways obstructive diseases (asthma, COPD, asthma-COPD overlap (ACO) and severe asthma) are different entities characterized by airflow obstruction. They may share common pathogenetic mechanisms allowing new therapeutic options for patients.
Methods: A review of the current literature is performed to investigate the common pathogenetic mechanisms among these medical conditions.
Results: Different specific cytokones are involved in both asthma and COPD pathogenesis, while ACO shares some of these cytokines placing the condition between the two entities. The cytokines regulate accumulations and contraction of airways smooth muscle cells which leads to different expression of airflow obstruction. A special cytokine, TSLP, is highlighted as playing a key role in the pathogenesis of asthma, COPD, ACO, and severe asthma which opens the opportunity for new treatment options for patients suffering from these conditions.
Conclusion: COPD, asthma, ACO and severe asthma share some common elements in their pathogenesis which opens the gate for new therapeutic options for the patients
 
Pathogenesis; Biomarkers; Inflammation; Biologics
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2024-3828.pdf

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Plamen Todorov Titorenkov and Milena Dimitrova Encheva. Asthma, COPD, the "asthma-COPD" syndrome and severe asthma - relatives or "incidental strangers"?. World Journal of Advanced Research and Reviews, 2024, 24(3), 1354-1363. Article DOI: https://doi.org/10.30574/wjarr.2024.24.3.3828

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