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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in March 2026 (Volume 29, Issue 3) Submit manuscript

Evaluation of anthropometric and lipid profile changes at different trimesters among pregnant women attending antenatal care in Nnewi, Anambra State, Nigeria

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  • Evaluation of anthropometric and lipid profile changes at different trimesters among pregnant women attending antenatal care in Nnewi, Anambra State, Nigeria

Chidiadi M. Njoku 1, *, Samuel C. Meludu 2, Jude A. Onuegbu 1, Chidimma Okafor 3, Nosakhare O. Osakue 4 and Joy I. Onuora 5

1 Department of Chemical Pathology, faculty of basic clinical Sciences, Nnamdi Azikiwe University, Awka.

2 Department of Human Biochemistry, faculty of basic medical Sciences, Nnamdi Azikiwe University Awka.

3 Department of Obstetrics and Gyneacology, Faculty of Medicine, Nnamdi Azikiwe University, Awka.

4 Department of Clinical Chemistry, faculty Medical Laboratory Sciences, Nnamdi Azikiwe University Awka.

5 Department of Medical Laboratory Sciences, faculty of health sciences and technology, Chukwuemeka Odumegwu Ojukwu University, Igbariam.

Research Article

World Journal of Advanced Research and Reviews, 2025, 27(01), 818-822

Article DOI: 10.30574/wjarr.2025.27.1.2471

DOI url: https://doi.org/10.30574/wjarr.2025.27.1.2471

Received on 18 May 2025; revised on 01 July 2025; accepted on 04 July 2025

Background: Regular physiological changes in pregnancy pose a metabolic challenge to individuals due to modifications the body makes for fetal growth and development, resulting in increased insulin resistance, inflammation and alterations in body composition, lipid levels and haemodynamic factors. 

Objective: This study evaluates the lipid profile changes at different trimesters of pregnancy in pregnant women with proteinuria and glycosuria in Nnewi Anambra State. 

Methods: A cross-sectional comparative study was conducted involving two hundred and fifty-two pregnant women categorized by trimester. Anthropometric and biochemical parameters including triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) were measured. TG/HDL was calculated.

Results: Significant trimester-dependent changes were observed in TG (p<0.001), HDL-C (p=0.017), and TG/HDL-C ratio (p<0.001). Post-hoc analysis indicated elevated TG and TG/HDL-C ratio in third trimester and peak HDL-C in second trimester. 

Conclusion: TG, HDL-C, and TG/HDL-C ratio may serve as early biomarkers for identifying at-risk pregnancies. Monitoring these may aid in reducing adverse outcomes and long-term maternal morbidity.

Pregnancy; Triglyceride; HDL-C; TG/HDL-C Ratio

https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2025-2471.pdf

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Chidiadi M. Njoku, Samuel C. Meludu, Jude A. Onuegbu, Chidimma Okafor, Nosakhare O. Osakue and Joy I. Onuora. Evaluation of anthropometric and lipid profile changes at different trimesters among pregnant women attending antenatal care in Nnewi, Anambra State, Nigeria. World Journal of Advanced Research and Reviews, 2025, 27(1), 818-822. Article DOI: https://doi.org/10.30574/wjarr.2025.27.1.2471

Copyright © Author(s). All rights reserved. This article is published under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits use, sharing, adaptation, distribution, and reproduction in any medium or format, as long as appropriate credit is given to the original author(s) and source, a link to the license is provided, and any changes made are indicated.

All statements, opinions, and data contained in this publication are solely those of the individual author(s) and contributor(s). The journal, editors, reviewers, and publisher disclaim any responsibility or liability for the content, including accuracy, completeness, or any consequences arising from its use.

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