1 Department of Galenic Pharmacy and Pharmaceutical Legislation, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Cameroon.
2 Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I.
3 Department of Dermatology, Gynecological-Obstetric Hospital, Yaounde, Cameroon.
4 Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Ebolowa, Cameroon.
5 Institute of Medical Research and Studies on Medicinal Plants, Cameroon.
World Journal of Advanced Research and Reviews, 2025, 27(01), 082-089
Article DOI: 10.30574/wjarr.2025.27.1.2500
Received on 07 April 2025; revised on 28 June 2025; accepted on 30 June 2025
This study focused on the development of an anti-dandruff shampoo based on an aqueous extract of Azadirachta indica (neem) leaves, a plant known for its antifungal and anti-inflammatory properties.
The extraction was performed by maceration, followed by qualitative and quantitative phytochemical screening. Shampoo formulations were developed with 2% neem extract and evaluated physicochemically (pH, viscosity, foamability), microbiologically and dermatologically. A single-blind pilot study was conducted on 30 adult women suffering from mild to moderate dandruff.
Phytochemical screening revealed richness in flavonoids, tannins, and phenolic compounds. Formulation F3 showed optimal characteristics, including a suitable pH (5.7), good microbiological stability, and satisfactory skin tolerance. After four weeks of use, participants who used the neem shampoo showed a significant improvement in symptoms: reduced flaking, relief of itching, and improved scalp condition. No adverse effects were observed.
These results confirm the anti-dandruff efficacy of the shampoo, attributed to the bioactive properties of neem extract. The product thus presents a promising natural alternative to conventional treatments, with a good safety profile and appreciable cosmetic acceptability.
Azadirachta indica; Shampoo; Anti-dandruff; Formulation; Quality control
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Charlotte Vanessa Soppo Lobe Emanda, Grâce Anita Nkoro Ombede, Astrid Tayipovi Saidou, Moïse Henri Julien Nko’o, Félécité Chimène Benga Mekoulou, Martin Gogonet Emanda Ekoudi, Jacqueline Saurelle Foumane Maniepi Ngouopiho, Priscilla Bernadette Ndzie Maniben and Nnanga Nga. Development and evaluation of an anti-dandruff shampoo based on aqueous extract of Azadirachta indica (neem) leave. World Journal of Advanced Research and Reviews, 2025, 27(1), 082-089. Article DOI: https://doi.org/10.30574/wjarr.2025.27.1.2500