Challenges in creating diabetes mellitus animal model for physiological research
1 Faculty of Medicine, Universitas Airlangga Indonesia.
2 Department of Anatomy, Histology, and Pharmacology, Faculty of Medicine Universitas Airlangga Indonesia.
3 Department of Anatomical Pathology, Faculty of Medicine Universitas Airlangga Indonesia.
2 Department of Anatomy, Histology, and Pharmacology, Faculty of Medicine Universitas Airlangga Indonesia.
3 Department of Anatomical Pathology, Faculty of Medicine Universitas Airlangga Indonesia.
Review Article
World Journal of Advanced Research and Reviews, 2023, 20(03), 263–269
Article DOI: 10.30574/wjarr.2023.20.3.2445
Publication history:
Received on 17 October 2023; revised on 28 November 2023; accepted on 01 December 2023
Abstract:
Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from abnormalities in insulin secretion, insulin action, or both. Diabetes mellitus is one of the global health problems, and its prevalence continues to increase from year to year. Diabetes mellitus has several types, among which the most commonly encountered are type 1 diabetes and type 2 diabetes. Studies related to diabetes mellitus need to be conducted to understand preventive and curative measures that can be taken to address this disease. There are various methods that can be used to study diabetes mellitus, one of which is using experimental animals. This article briefly explains various methods that can be used in inducing diabetes in experimental animals, along with the advantages and disadvantages of these methods.
Keywords:
Alloxan; Animal Model; Diabetes Mellitus; Streptozotocin
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0