1 Respiratory Virus Laboratory, National Public Health Institution, Conakry, Republic of Guinea.
2 Molecular Biology Laboratory, Department of Biology, Faculty of Sciences, Gamal Abdel Nasser University of Conakry, BP 1147, Conakry, Republic of Guinea.
3 Multidisciplinary Laboratory, Department of Biology, Faculty of Science and Technology, University of N'Zérékoré, BP 50, N'Zérékoré, Republic of Guinea.
4 BioHafia Laboratory, Department of Biology, Faculty of Science and Technology, University of Labé, BP 210, Labé, Republic of Guinea.
5 National Agency for Health Security, Ministry of Health and Public Hygiene, Conakry, Republic of Guinea.
World Journal of Advanced Research and Reviews, 2025, 25(02), 2527-2534
Article DOI: 10.30574/wjarr.2025.25.2.0505
Received on 07 January 2025; revised on 21 February 2025; accepted on 24 February 2025
The coronavirus pandemic (COVID-19) is a potentially fatal disease that has caused a global public health crisis. Its treatment is symptomatic because until now the WHO has not approved an effective treatment against this disease. This is why today hope is turned to vaccination to curb this global pandemic. The presence of anti-SARSCoV-2 antibodies in the serum of sick (symptomatic or asymptomatic) and vaccinated individuals must be evaluated for the proper understanding of natural or adaptive immunity.
We conducted a cross-sectional study of 6 months duration. The working methodology consisted in the determination of anti-SARSCoV-2 antibodies in the serum of unvaccinated (asymptomatic) and vaccinated persons by the Elisa method.
We found 33.66% positive cases in unvaccinated persons and 93.51% positive cases in vaccinated persons. The most affected commune in both groups (vaccinated and non-vaccinated) was Ratoma with respectively 35% and 65%. There were 57.14% males in the unvaccinated group versus 64.98% in the unvaccinated group. The age group that developed the most antibodies in both study groups was 20-39 years old with 35% and 65% respectively. The optical density was higher in vaccinated persons than in unvaccinated persons.
In sum, according to the results found in this study, we must remember that more antibodies are developed in the vaccinated population than in the non-vaccinated.
COVID-19; Seroprevalence; G Antibodies; Optical Density
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Mamadou Aliou SAMPOU, Mamadou Bhoye KEITA, Abdoulaye Oury BARRY, Sakoba KEITA, Sory Condé, Ahmadou Sadjo DIALLO, Taliby Dos CAMARA, Thierno Ibrahima DIALLO, Aboubacar SOW, Dian Bhoye DIALLO, Bassala TRAORE, Pepe TOHONAMOU, Moussa KEITA, Aboubacar SOUMAH, Maimouna DIALLO, Marie HABA, Sidiki BAMBA and Ibrahima Fanè. Seroprevalence of people vaccinated or not against COVID-19 in the city of Conakry. World Journal of Advanced Research and Reviews, 2025, 25(2), 2527-2534. Article DOI: https://doi.org/10.30574/wjarr.2025.25.2.0505