Evaluation of salivary flow rate and composition in hypertensive patients taking antihypertensive drugs consuming

Background: Hypertension patients are recorded by WHO to increase continuously along with the increase in population, accounting for 29% of the world's citizens suffering from hypertension. Most people with hypertension take hypertension drugs. The use of antihypertensive drugs varies and can cause several side effects on the oral cavity, especially the salivary flow rate. The purpose of this study was to evaluate the flow rate and composition of saliva in hypertensive patients who take hypertension drugs. This study uses a systematic review method by searching for articles related to evaluating the flow rate and composition of saliva in hypertensive patients who take antihypertensive drugs that have been published in journals. The literature search was conducted in April 2023 through google scholar and PubMed. Journals were selected based on inclusion and exclusion criteria through a critical appraisal process. 

Result: The use of antihypertensive drugs, such as captopril and amlodipine, significantly decreased the salivary flow rate compared to the control group. In amlodipine users, 93.33% experienced a very low reduction in salivary flow rate, while in captopril users it was 83.33%. 

Conclusion: Regular use of the antihypertensive drugs captopril and amlodipine may decrease salivary flow rate.