Determination of function of regulatory T cells and associated cytokines in colorectal cancer patients at the local site and peripheral blood: A comparative study
1 Department of Transplant Immunology & Immunogenetics, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
2 Dr. Bhimrao Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi (AIIMS), India.
Research Article
World Journal of Advanced Research and Reviews, 2023, 19(01), 736–743
Article DOI: 10.30574/wjarr.2023.19.1.1356
Publication history:
Received on 24 May 2023; revised on 12 July 2023; accepted on 15 July 2023
Abstract:
Colorectal cancer (CRC) is a common lethal cancer worldwide as genetic as well as environmental factors influence it. CRC is heterogeneous, with a diverse and plastic immune cell infiltration. Among the numerous tumoral antigens that could induce an immune response in CRC, the carcinoembryonic antigen is the most studied, but its immunogenicity remains low. Infiltrate of CD3+ and CD8+ T cells into CRC tumors has been validated worldwide as a valuable indicator of patient prognosis. Even though a high T cell infiltrate is a better indicator of patient survival than traditional histologically based staging methods, the immune response in colorectal cancer (CRC) has not yet been reliably and effectively harnessed to treat patients of all stages and types of disease. The management of colorectal cancer is fraught with challenges, and the lack of reliable biomarkers and laboratory tests is a major bottleneck in existing treatment strategies. This study explores and attempts to resolve some of these issues.
Keywords:
Colorectal cancer (CRC); Treg cells; Cytokines; Peripheral blood; Immunomodulation
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