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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in March 2026 (Volume 29, Issue 3) Submit manuscript

A new neonatal and paediatric TCI theory proposal. Second Part: Algorithm and software construction

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  • A new neonatal and paediatric TCI theory proposal. Second Part: Algorithm and software construction

L. Milella 1, * and P. Maiorano 2

1 Neonatal and Paediatric General Anaesthesia and ICU-Neonatal and Paediatric Cardiac Anaesthesia and ICU Paediatric Hospital “John XXIII” Viale Amendola, 207-70128-Bari-Italy.
2 ”Leonardo Company”- Viale del lavoro , 101, Taranto-Italy.
 
Review Article
World Journal of Advanced Research and Reviews, 2024, 24(03), 3020-3058
Article DOI: 10.30574/wjarr.2024.24.3.3702
DOI url: https://doi.org/10.30574/wjarr.2024.24.3.3702
 
Received on 13 November 2024; revised on 22 December 2024; accepted on 24 December 2024
 
The first aim of the second part of the new PK/PD software for TCI Driven Anaesthesia in Neonates, Toddlers and Elderly patients’ “Proposal”, is to give details about the speculative theoretical and applicative mathematical pathways that led us to develop a new algorithm and build up the applicative software.
The second aim is to explain and demonstrate the theory applicability to practical use.
The final intent is to describe the applicative software, and which is the line of speculations that lead us to choose and decide the compulsory covariate to be use in the development of the theory confirmation.
The principles of the theory  proposal starts from the definition of  new covariate theory  values and hypothetic values of “Total Anaesthesia Live Drug Detection and Elimination ” driven by a different pharmacological point of view; a new mathematical equation has been propose and the first consequence of such equation is that “Creatinine or Drug  Clerance” could not to be only indexed  starting from referred standard concepts , for example, to renal or hepatic elimination of anaesthetic drugs, but must be considered a much more complex event when we speculate about “Dynamic Cells Growth Systems” ,(Neonates , Toddlers, Elderly subjects),   and not “Static Cells Growth Systems”  as we can consider subjects ranging from 30 kgs weight up to 70 years of age, when  a “Rapid Cells Decay Slope Curve” starts  in compulsory mode.
 
Paediatric Anaesthesia; Rapid Cells Growth Systems; Allometry; Allometric Pharmacology; Applicative TCI Software; Quantic Physic Laws
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2024-3702.pdf

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L. Milella and P. Maiorano. A new neonatal and paediatric TCI theory proposal. Second Part: Algorithm and software construction. World Journal of Advanced Research and Reviews, 2024, 24(3), 3020-3058. Article DOI: https://doi.org/10.30574/wjarr.2024.24.3.3702

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