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eISSN: 2582-8185 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in March 2026 (Volume 29, Issue 3) Submit manuscript

Study of the effect of direct acting antivirals (DAAs) on fibrosis in chronic hepatitis C patients using transient elastography

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  • Study of the effect of direct acting antivirals (DAAs) on fibrosis in chronic hepatitis C patients using transient elastography

Alaa Aboud Mohammed 1, *, Dina Attia 1, Basel Abdelmonem Ebeid 1 and Mariam Boulous Ibrahim 2

1 Department of Gastroenterology, Hepatology and Endemic Medicine, Faculty of medicine Beni-Suef University, Egypt.
2 Faculty of Medicine, Minia University, Egypt.
 
Research Article
World Journal of Advanced Research and Reviews, 2021, 10(02), 135–145
Article DOI: 10.30574/wjarr.2021.10.2.0213
DOI url: https://doi.org/10.30574/wjarr.2021.10.2.0213
 
Received on 05April 2021; revised on 08May 2021; accepted on 11 May 2021
 
Back ground: As DAA agents are leading to enormous cure rates, so identifying and monitoring patients who remain at a high complication risk after achieving SVR continue to be a critical issue. Numerous validated methods for noninvasive measurement of liver fibrosis can be used in the management of HCV infection.
Methods study: A total of 50 Egyptian chronic HCV patients eligible for treatment with DAAs were enrolled in this prospective study. All subjects selected from Virology Unit of Tropical Medicine Department, Faculty of Medicine, Beni-Suef University received DAAs (SOV DCV) the endpoint was a sustained virologic response at 12 (SVR12) weeks post-treatment. All participants were evaluated non-invasively by Liver Stiffness Measurement (LSM) by Fibro Scan before DAAs treatment, and 6 months post-treatment.
Results: SVR achieved by DAAs therapy was 96 % and was associated with significant improvement (p Ë‚0.05) of non-invasive fibrosis markers (FIB-4, APRI score, and LSM by Fibro Scan) from baseline compared to 6 months post-treatment. Using fibro scan regression of fibrosis in 30/45 patients (66%). Liver inflammation and synthetic functions also improved on follow up 12w and 6m post treatment.
Conclusion: Regression of Liver inflammation and fibrosis in chronic hepatitis C patients post treatment with SOF DCV
 
DAAs; Fibrosis; Fibro scan
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2021-0213.pdf

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Alaa Aboud Mohammed, Dina Attia, Basel Abdelmonem Ebeid and Mariam Boulous Ibrahim. Study of the effect of direct acting antivirals (DAAs) on fibrosis in chronic hepatitis C patients using transient elastography. World Journal of Advanced Research and Reviews, 2021, 10(2), 135-145. Article DOI: https://doi.org/10.30574/wjarr.2021.10.2.0213

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