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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in April 2026 (Volume 30, Issue 1) Submit manuscript

The effect of hydrolase enzyme on antibiofilm activity in oral cavity microbes

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  • The effect of hydrolase enzyme on antibiofilm activity in oral cavity microbes

Vian Taurusanto Tjokropudjiono 1, *, Michelle Fidelia Alexandra 1, Gabriel Marsuita 1 and Tantiana 2

1 Faculty of Dental Medicine, Airlangga University, Surabaya, Indonesia.
2 Department of Biology Oral, Faculty of Dental Medicine, Airlangga University, Surabaya, Indonesia.
 
Research Article
World Journal of Advanced Research and Reviews, 2024, 24(03), 263-271
Article DOI: 10.30574/wjarr.2024.24.3.3662
DOI url: https://doi.org/10.30574/wjarr.2024.24.3.3662
 
Received on 22 October 2024; revised on 30 November 2024; accepted on 03 December 2024
 
Background : Every surface of the human body that comes into contact with the outside environment is covered with a layer of microorganisms called the human microbiome, characterized by species diversity and a high number of cells. Biofilms are surface-related, three-dimensional multicellular structures whose integrity depends on the extracellular matrix produced by their constituent bacteria. Hydrolase enzymes are a class of enzymes belonging to the anti-biofilm enzymes and are categorized as polysaccharide-degrading enzymes, proteolytic enzymes, and antiquorum sensing enzymes.
Purpose : To know the effect of hydrolase enzyme towards antibiofilm activity of oral cavity microbe.
Method : The method used is literature study by searching databases from various national and international sources.
Results : There is an anti-biofilm effect of several types of hydrolase enzymes on oral microbes such as P. aeruginosa, S. aureus, E. faecalis, and E. coli. The greatest effect was found in the enzymes PelAh & PslGh with the mechanism of action of polysaccharide-degrading enzymes and their microbial target, P. aeruginosa, can reduce biofilm biomass by 58-94%.
Conclusion : Of the several existing mechanisms can provide different effects depending on the microbial target.
 
Antibiofilm; Hydrolases Enzyme; Oral Microbiome; Oral Cavity; Microbes
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2024-3662.pdf

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Vian Taurusanto Tjokropudjiono, Michelle Fidelia Alexandra, Gabriel Marsuita and Tantiana. The effect of hydrolase enzyme on antibiofilm activity in oral cavity microbes. World Journal of Advanced Research and Reviews, 2024, 24(3), 263-271. Article DOI: https://doi.org/10.30574/wjarr.2024.24.3.3662

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