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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in March 2026 (Volume 29, Issue 3) Submit manuscript

Gastro-retentive drug delivery system of hypertension drug: Formulation and evaluation study

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  • Gastro-retentive drug delivery system of hypertension drug: Formulation and evaluation study

Suryakant Shrivastava *, Manoj Goyal and Arti Soni

Shri Ramnath Singh Mahavidyalaya (Pharmacy) Gormi, Bhind (M.P), India.
 
Research Article
World Journal of Advanced Research and Reviews, 2024, 23(02), 2094-2105
Article DOI: 10.30574/wjarr.2024.23.2.2512
DOI url: https://doi.org/10.30574/wjarr.2024.23.2.2512
 
Received on 11 July 2024; revised on 21 August 2024; accepted on 23 August 2024
 
Introduction: Hypertension, a major global health concern, necessitates effective management through sustained drug delivery systems. Gastro-retentive drug delivery systems (GRDDS) offer a strategic advantage by prolonging the residence time of drugs in the stomach, thus enhancing therapeutic efficacy and patient adherence. This study aims to develop and evaluate a GRDDS for antihypertensive drugs to achieve extended gastric retention and controlled release.
Methods: A GRDDS was formulated using a combination of hydrophilic and hydrophobic polymers to ensure buoyancy and extended gastric retention. The formulation process involved selecting optimal polymer concentrations and incorporating release-modulating agents. In vitro evaluations included buoyancy studies, swelling behavior analysis, and drug release kinetics under simulated gastric conditions. Additionally, in vivo studies were conducted to assess the system’s gastric retention and pharmacokinetic profile in an animal model.
Conclusion: The developed GRDDS demonstrated effective gastric retention and a controlled release profile for the antihypertensive drug. In vitro results confirmed the system’s ability to maintain buoyancy and provide sustained drug release. In vivo studies supported these findings, showing improved drug bioavailability and stable plasma levels. This GRDDS represents a promising advancement in hypertension management, potentially enhancing therapeutic outcomes and patient compliance. Further research and clinical trials are recommended to validate these preclinical results and optimize the system for broader application.
 
Gastro-retentive Drug Delivery System (GRDDS); Antihypertensive Drug; Controlled Release; Formulation
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2024-2512.pdf

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Suryakant Shrivastava, Manoj Goyal and Arti Soni. Gastro-retentive drug delivery system of hypertension drug: Formulation and evaluation study. World Journal of Advanced Research and Reviews, 2024, 23(2), 2094-2105. Article DOI: https://doi.org/10.30574/wjarr.2024.23.2.2512

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