1 European University "Kallos"; XVIII Hrvatske brigade br. 8, 75000 Tuzla, Bosnia and Herzegovina.
2 JZU „Dom zdravlja“Živinice, ul. Alije Izetbegovića br.17, 75270 Živinice, Bosnia and Herzegovina.
3 Cantonal Administration for Inspection Affairs of Tuzla Canton, Rudarska 72, 75 000 Tuzla, Bosnia and Herzegovina.
Research Article
World Journal of Advanced Research and Reviews, 2024, 23(02), 1938-1947
Article DOI: 10.30574/wjarr.2024.23.2.2490
Received on 08 July 2024; revised on 19 August 2024; accepted on 21 August 2024
The aim of the study is to determine the effect of beta-blockers on lipid status, triglycerides and Body Mass Index (BMI) in patients using beta-blockers in the treatment of arterial hypertension. Our study included 120 patients at the Public Health Institution "Dom zdravlja" Živinice. The participants were monitored over a period of 3 years. Measurements were made after 12, 24 and 36 months of treatment. Patients were divided into two groups. The experimental group included 60 patients, who used beta-blockers in the treatment of arterial hypertension. The control group included 60 patients who used other antihypertensives as their first choice medication in the treatment of arterial hypertension. By monitoring cholesterol and triglyceride levels in patients using beta-blockers and other antihypertensive medications, and comparing these values within the group, no statistically significant difference in cholesterol and triglyceride levels was found in patients who used beta-blockers after 12, 24, and 36 months of treatment. There was also no statistically significant effect of therapy on the change in cholesterol and triglyceride values at observed time intervals, nor was there a statistically significant difference between these values. BMI monitoring showed a statistically significant difference between patients using beta-blockers and other antihypertensive drugs, with patients using beta-blockers having a higher BMI after 36 months of treatment. There was no statistically significant difference in BMI between patients using bisoprolol and carvedilol and patients using other beta-blockers, but patients using bisoprolol and carvedilol had lower BMI values. In studies conducted in recent years, it has been noted that many beta-blockers cause dose-dependent adverse metabolic effects on glucose and lipid metabolism, with the most adverse metabolic effects observed in patients treated with conventional non-selective beta-blockers. On the other hand, more favorable metabolic profile have drugs with β1 selective activity, such as atenolol and metoprolol, especially those with intrinsic sympathomimetic activity such as pindolol. In fact, with these beta-blockers, the adverse metabolic effects appear to be less prominent. In conclusion, beta-blockers do not lead to an increase in cholesterol and triglycerides, but they do lead to an increase in BMI in patients with arterial hypertension
BMI; Metabolism; Beta-blockers; Lipid status
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Halida Mahmutbegović Poljaković, Mithat Tabaković, Eldina Halilović, Halid Mahmutbegović, Elvedin Osmanović and Aldijana Mahmutović Milićević. Beta-blockers and their impact on metabolic processes. World Journal of Advanced Research and Reviews, 2024, 23(2), 1938-1947. Article DOI: https://doi.org/10.30574/wjarr.2024.23.2.2490