Incidental skin manifestation of trisomy 12 chronic lymphocytic leukemia
1 Department of Internal Medicine, HCA Healthcare; Mountain View Hospital, Las Vegas, NV, USA.
2 Department of Hematology and Oncology, HCA Healthcare; Mountain View Hospital, Las Vegas, NV, USA.
Case Study
World Journal of Advanced Research and Reviews, 2023, 17(02), 517–521
Article DOI: 10.30574/wjarr.2023.17.2.0258
Publication history:
Received on 01 January 2023; revised on 10 Februay 2023; accepted on 13 February 2023
Abstract:
Chronic lymphocytic leukemia (CLL) is one of the most prevalent B-cell cancers for people over the age of 65. CLL is commonly comorbid with trisomy 12, as reported in up to 20% of cases. In our case, trisomy 12 was incidentally found on this patient. Its pathophysiology is quite unclear but has played a role in the side effect profile of CLL. Trisomy 12 with CLL has been shown to have increased risk for side effects like thrombocytopenia, Richter transformation and hematological cancers. The goal of this case presentation is to discuss a case of CLL with cutaneous manifestations and to look at the role that trisomy 12 can play.
Keywords:
Chronic lymphocytic leukemia; Trisomy 12; CD5 B-cell; Flow cytometry; Leukemia cutis
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0