Auricularia polytricha: A promising medicinal mushroom for combination therapy of colorectal cancer and understanding its potential mechanism of action

Gloria Claudia Kastanja 1, Aulia Rahmi Pawestri 2, Zahrah Firdaus 3, Felita Galih Perwita Sari 3, Michelle Anisa Ujianto 3, Khonsaa Aadilah 3, Elsafira Akrama Nabilahasna 3, Edwin Widodo 4, Eviana Norahmawati 5, Sofy Permana 6 and Agustina Tri Endharti 2, 7, *

1 Bachelor Program of Medical, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Indonesia.
2 Department of Parasitology, Faculty of Medicine, Universitas Brawijaya, Indonesia.
3 Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Brawijaya, Indonesia.
4 Department of Physiology, Faculty of Medicine, Universitas Brawijaya, Indonesia.
5 Department of Pathology Anatomy, Faculty of Medicine, Universitas Brawijaya, Indonesia.
6 Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Indonesia.
7 Biomedical Central Laboratory, Faculty of Medicine, Universitas Brawijaya, Indonesia. 
 
Review Article
World Journal of Advanced Research and Reviews, 2023, 17(02), 365–377
Article DOI: 10.30574/wjarr.2023.17.2.0152
 
Publication history: 
Received on 18 December 2022; revised on 29 January 2023; accepted on 31 January 2023
 
Abstract: 
The Global Burden of Cancer (GLOBOCAN) revealed that there were 1,931,590 new cases and 935,173 deaths due to colorectal cancer in 2020. Treatment for colorectal cancer tends to be invasive and costly. Therefore, further research is needed on non-invasive complementary therapies that are safe and can be used to reduce the probability of recurrence in colorectal cancer patients at an affordable cost. The systematic literature review synthesized resources and presented them in a narrative review. Four databases, including PubMed, Research Gate, ProQuest, and Science Direct, were used to conduct the systematic reviews by following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) criteria. In this review, 36 articles were analyzed descriptively to help describe and summarize the data constructively. The results showed that complementary colorectal cancer therapy with Auricularia polytricha which contains active compounds, such as flavonoids, phenols, and beta-glucans, can increase the expression of miRNA-9, miRNA-217, miRNA-210, miRNA200c, and miRNA-132 which can improve the prognosis of colorectal cancer.
 
Keywords: 
Colorectal cancer; miRNA; Auricularia polytricha; Flavonoids; Phenol; Beta glucan
 
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Copyright information: 
Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0

 

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