Antibiofilm formation activities of ethanol extracts from Curcuma domestica rhizome against bacteria resistant Pseudomonas aeruginosa
1 Department of Pharmacology and Toxicology Faculty of Pharmacy Universitas Sumatera Utara.
2 Research and Innovation Agency (BRIN), Kawasan PUSPIPTEK Serpong, Tangerang Selatan, Banten 15314, Indonesia.
Research Article
World Journal of Advanced Research and Reviews, 2023, 17(01), 963–966
Article DOI: 10.30574/wjarr.2023.17.1.1400
Publication history:
Received on 11 November 2022; revised on 21 December 2022; accepted on 24 December 2022
Abstract:
The Biofilm P.aeruginosa communities are characterized by close juxtaposition of bacterial cells and the presence of an exopolysaccharide matrix that surrounds the bacterial population. Many reports have postulated that the exopolysaccharide matrix provides an effective barrier that restricts penetration of chemically reactive biocides, cationic antibiotics and antimicrobial peptides. This study aims to antibiofilm formation activities of ethanol extract from Curcuma domestica against Pseudomonas aeruginosa resistant bacteria. These antibiofilm formation was determined using a modified-method of microdilution assay. Ethanol extract of C. domestica strong activity against P.aeruginosa with Anti-biofilm activity was observed through biofilm inhibition and degradation activities, determined by Cristal Violet assay. Data were analyzed using ANOVA test and Tukey HSD post hoc test. The significant inhibition of P.aeruginosa the biofilm degradation was obtained at a concentration of 31.2 µg/ml until 250 µg/ml. The ethanol extract of C. domestica have potency as alternative antibiofilm formation against selected bacteria resistant.
Keywords:
Antibiofilm Formation; Curcuma domesticae; Pseudomomas aeruginosa; Optical density
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