1 Department of Biology, Clinical Biochemistry Laboratory, Arrazi Hospital, Mohamed VI Hospital University, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco.
2 Department of Biology, Microbiology Laboratory, Arrazi Hospital, Mohamed VI Hospital University, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco.
Research Article
World Journal of Advanced Research and Reviews, 2024, 22(02), 1973-1979
Received on 14 April 2024; revised on 25 May 2024; accepted on 28 May 2024
Background: The objective of our study is to evaluate the effectiveness and contribution of the C-reactive protein dosage, widely used in our context, in the early detection of neonatal sepsis and diagnostic orientation.
Methods: Retrospective study, conducted at the clinical biochemistry laboratory, in collaboration with the microbiology laboratory, in newborns admitted to the neonatology department for management of confirmed or suspected neonatal infection, during a period extending from January to December 2020.
Results: A total of 300 blood cultures were performed. The sex ratio M/F: 1,38. The average age was 11.24 days. There were 148 positive cultures among which there were 120 positive CRP, that is 81%. And 152 sterile cultures with 50 positive CRP. The mean CRP value in the positive cultures was 62.67 mg/L. It was 15.53 mg/l in sterile cultures. The chi-square statistic calculated for our analysis is 70.906 with a significance level (alpha) of 0.05. The point-biserial correlation coefficient (r_pb) for this study is 1.51
Conclusion: Although there are currently more specific and sensitive early markers of inflammation, the C-reactive protein determination, widely used in our context, provides sufficient sensitivity and specificity in the diagnostic orientation of neonatal sepsis.
C-reactive protein; Screening; Biomarkers; Newborns; Septicemia
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Sara Harrar, Soukaina El Aassri, Yazid El Alaoui Boufares, Taoufik Benhoumich, Asma Lamrani Hanchi, Nabila Soraa and Siham Aboulmakarim. Contribution of C-reactive protein in the detection of sepsis in newborns: A cross-sectional study. World Journal of Advanced Research and Reviews, 2024, 22(2), 1973-1979. Article DOI: https://doi.org/10.30574/wjarr.2024.22.2.1609