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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in March 2026 (Volume 29, Issue 3) Submit manuscript

Addressing olanzapine-induced diabetic ketoacidosis in a major depressive disorder case

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  • Addressing olanzapine-induced diabetic ketoacidosis in a major depressive disorder case

EL FELLAH SARA *, ADALI IMANE and MANOUDI FATIHA

Research team for mental health, University Psychiatric Service IBN Nafis Hospital, Mohamed VI University Hospital, Marrakech. Morocco.
 
Case Study
World Journal of Advanced Research and Reviews, 2024, 22(02), 1059-1062
Article DOI: 10.30574/wjarr.2024.22.2.1349
DOI url: https://doi.org/10.30574/wjarr.2024.22.2.1349
 
Received on 23 March 2024; revised on 10 May 2024; accepted on 13 May 2024
 
This case study highlights a critical incidence of olanzapine-induced diabetic ketoacidosis (DKA) in a 36-year-old female patient treated for major depressive disorder with psychotic features. The patient developed severe DKA after the initiation of olanzapine, despite initially normal metabolic parameters and a low starting dose. This report underscores the acute metabolic derangement facilitated by olanza- pine, necessitating a comprehensive and urgent medical approach. The clinical intervention involved discontinuing olanzapine and initiating a multidisciplinary treatment strategy, which included medical management of DKA and psychiatric adjustments using alternatives with a lower metabolic risk. This case emphasizes the necessity for regular metabolic monitoring and the potential need for tailored psychiatric medication strategies to prevent severe side effects, highlighting the unpredictability of antipsychotic- induced metabolic disturbances and advocating for a holistic, patient-centered approach in psychiatric care.
 
Olanzapine; Diabetic Ketoacidosis; Major Depressive Disorder; Psychiatric Medication; Metabolic Disturbances; Case Study; Antipsychotic Side Effects; Patient-Centered Care
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2024-1349.pdf

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EL FELLAH SARA, ADALI IMANE and MANOUDI FATIHA. Addressing olanzapine-induced diabetic ketoacidosis in a major depressive disorder case. World Journal of Advanced Research and Reviews, 2024, 22(2), 1059-1062. Article DOI: https://doi.org/10.30574/wjarr.2024.22.2.1349

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