Oleanolic acid as a potential drug molecule: A review
Shivajirao S Jondhle college of Pharmacy, Asangaon, Thane 421601, Maharashtra, India.
Review Article
World Journal of Advanced Research and Reviews, 2023, 17(01), 249-254
Publication history:
Received on 25 November 2022; revised on 05 January 2023; accepted on 07 January 2023
Abstract:
Objective: Oleanolic acid is traditionally used medicinal remedies in India. Oleanolic acid or oleanic acid is a naturally occurring pentacyclic triterpenoid related to betulinic acid. It is widely distributed in food and plants where it exists as a free acid or as an aglycone of triterpenoid saponins.
Key findings: Oleanolic acid is relatively non-toxic, hepatoprotective, and exhibits antitumor and antiviral properties. It was found to exhibit weak anti-HIV and weak anti-HCV activities in vitro, but more potent synthetic analogs are being investigated as potential drugs.
Conclusion: This review is an overall overview of the existing pharmacology of Oleanolic acid, helping to fuel further research in the various unexplored activities that are attributable to this plant.
Keywords:
Oleanolic acid; Hepatoprotective; Antitumor; Antiviral; Antibacterial
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