Department of Dermatology and Venereology, Ibn Rochd University Hospital, Casablanca, Morocco.
Editorial
World Journal of Advanced Research and Reviews, 2024, 21(03), 862-864
Article DOI: 10.30574/wjarr.2024.21.3.0741
Received on 26 January 2024; revised on 04 March 2024; accepted on 07 March 2024
Fahr's syndrome is a rare condition characterized by the presence of calcifications in the basal ganglia, typically secondary to a disorder of phosphocalcic metabolism, primarily hypoparathyroidism. It is generally challenging to clinically suspect as it can remain asymptomatic or manifest with diverse symptoms not corresponding to any specific clinical pattern. The dermatological expression of this syndrome is exceptional and is linked to hypoparathyroidism and hypocalcemia. In a hypocalcemic environment, keratinocytes exhibit significant proliferative activity, which may explain the pustular rash in our patients. Diagnosis relies on the presence of bilateral and symmetrical calcifications in the basal ganglia. Treatment involves calcium and vitamin D supplementation. Therefore, it is important to consider this syndrome in the presence of any aseptic pustulosis associated with disorders of phosphocalcic metabolism, particularly in cases with associated neuropsychiatric pathologies. We retrospectively report observations from six patients with Fahr's syndrome revealed through dermatological manifestations over a five-year period.
Fahr’s syndrome; Amicrobial pustulosis; Neuropsychiatric symptoms; Hypoparathyroidism; Central gray nuclei calcification
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Fatimazahrae Benhayoun, Fouzia Hali and Soumiya Chiheb. Fahr's syndrome with dermatological manifestation. World Journal of Advanced Research and Reviews, 2024, 21(3), 862-864. Article DOI: https://doi.org/10.30574/wjarr.2024.21.3.0741