Analytical method validation: A brief review
1 Department of Pharmacy, N.S.S. College of Pharmacy, Maharashtra State Board of Technical Education, Mumbai, India.
2 Department of Pharmaceutical Chemistry, N.S.S. College of Pharmacy, Maharashtra State Board of Technical Education, Mumbai, India.
Review Article
World Journal of Advanced Research and Reviews, 2022, 16(02), 389–402
Article DOI: 10.30574/wjarr.2022.16.2.1165
Publication history:
Received on 01 October 2022; revised on 08 November 2022; accepted on 10 November 2022
Abstract:
Validation is an applied approach to verify that a method is suitable to function as a quality control tool. The objective of any analytical measurement is to obtain consistent, reliable and accurate data. Validated analytical methods play a major role in achieving this goal. An analytical method consists of the techniques, method, procedure and protocol. Analytical method validation includes the determination of accuracy, precision, LOD, LOQ, linearity and range. The results from method validation can be used to moderator the quality, reliability and consistency of analytical results, which is an integral part of any good analytical practice. Validation of analytical methods is also required by most regulations and quality standards that impact laboratories. The main objective of this review article is to guide the young researchers to improve the quality of analytical method development and validation process.
Keywords:
Validation; Accuracy; Precision; Case study; Validation report
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