TNF-α, TNF-R1, TNF-R2 levels in women with normal pregnancy, preeclampsia, and preeclampsia with sepsis
Health Science, Faculty of Medicine, University of Wijaya Kusuma Surabaya, Surabaya, Indonesia.
Research Article
World Journal of Advanced Research and Reviews, 2022, 15(03), 358–365
Publication history:
Received on 17 August 2022; revised on 21 September 2022; accepted on 23 September 2022
Abstract:
Preeclampsia (PE) is a disorder in pregnancy with a worldwide prevalence of about 5-8% of cases. TNF is the main physiological mediator of the inflammatory process. These membrane-bound and soluble cytokines are biologically active. They have different affinities for two types of TNF receptors, apoptotic receptors (TNFR1) and non-apoptotic receptors (TNFR2). This study reveals the levels of TNF-α, TNF-R1, TNF-R2 in women with normal pregnancy, preeclampsia, and preeclampsia with sepsis. An observational analytic cross sectional research design is applied. The minimum number of sample is 14 women for each group (group 1: women with normal pregnancy, group 2: preeclampsia, and group 3: preeclampsia with sepsis). The results show that
· There is an increase in TNF- levels in preeclamptic women and in preeclamptic women with sepsis
· There is an increase in TNF-R1 receptor levels in preeclamptic women and in preeclamptic women with sepsis
There is an increase in TNF-R2 receptor levels in preeclamptic women and in preeclamptic women with sepsis.
Keywords:
TNF level; Women; Preeclampsia; Preeclampsia with sepsis
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