1 Department of Pharmacy, BBDIT, Duhai, Ghaziabad Uttar Pradesh, India.
2 Department of Pharmacy, Krishna Institute Bijnor, Near By -6 milestone Golbhag Chauraha Noorpur Road Bijnor (U.P) 246701, India.
3 Department of Pharmacy, Bansthali Vidyapith, Tonk Road Niwaru – 304022, India
4 Department of Pharmacy, Maharishi Markendeshwar College of Pharmacy, Mullana, Ambala, Haryana, India.
5 IIMT College of Medical Sciences, IIMT University, Ganga Nagar, Meerut, Uttar Pradesh, India – 250001, India.
6 Department of Pharmacy, Shivajirao S Jondhle College of Pharmacy, Asangaon, Thane Maharashtra. 421601, India.
7 Department of Pharmacy, Navsahyadri Institute of Pharmacy, Naigaon, Nasarapur, Pune, Maharashtra 412213, India.
8 College of Pharmaceutical Sciences, PIMS (DU), Loni (Bk)Tal Rahata, Dist. Ahmednagar, Maharashtra, India.
Research Article
World Journal of Advanced Research and Reviews, 2023, 20(03), 1102–1114
Article DOI: 10.30574/wjarr.2023.20.3.2565
Received on 30 October 2023; revised on 15 December 2023; accepted on 17 December 2023
Solid Lipid Nanoparticles (SLNs) have emerged as promising drug delivery systems with the potential to enhance the therapeutic efficacy of bioactive compounds. In this study, T. Cordifolia extract-loaded SLNs were developed and characterized for their application in the treatment of autoimmune hepatitis. T. Cordifolia, known for its immunomodulatory and anti-inflammatory properties, was chosen as the active ingredient. The formulations were systematically evaluated for drug-excipient compatibility, particle size, zeta potential, drug loading efficiency, drug release kinetics, encapsulation efficiency, in-vitro release, and stability. The results indicated "No Change" in drug-excipient compatibility, ensuring the formulation's stability. The SLNs exhibited nanoscale particle sizes (159.30 nm to 172.12 nm) with narrow size distributions, facilitating consistent drug delivery. Negative zeta potentials (-28.28 mV to -35.44 mV) indicated colloidal stability. High drug loading efficiencies (up to 32.23%) and controlled drug release kinetics were observed, suggesting the potential for sustained and targeted drug delivery. Encapsulation efficiencies of up to 83.41% highlighted efficient drug loading within the SLNs. In-vitro release studies revealed that SLN2 and SLN4 exhibited superior drug release profiles compared to other formulations. These findings indicate the potential of these formulations for controlled drug delivery. In-vivo efficacy studies in murine models of autoimmune hepatitis are recommended to assess the therapeutic benefits of T. Cordifolia extract-loaded SLNs. Additionally, stability studies demonstrated the maintenance of critical parameters, such as particle size, zeta potential, and drug loading efficiency, under different storage conditions.
Tinospora cordifolia; Solid Lipid Nanoparticles; Autoimmune hepatitis; Drug delivery; Immunomodulatory; Anti-inflammatory; Encapsulation efficiency; Drug release kinetics; Stability studies.
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Savisa Yadav, Pooja Rani, Kumari Shanno, Raman Kumari, Shamim, Tarmeen Ali, Nitin Chandrakant Mohire, Gita Nitin Mohire and Ravindra Bhimraj Laware. Development and characterization of Tinospora cordifolia extract-loaded SLNs for the treatment of autoimmune hepatitis. World Journal of Advanced Research and Reviews, 2023, 20(3), 1102-1114. Article DOI: https://doi.org/10.30574/wjarr.2023.20.3.2565