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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in April 2026 (Volume 30, Issue 1) Submit manuscript

The inhibitory effect of Sambiloto (Andrographis paniculata Nees) leaf extract on growth of Candida albicans

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  • The inhibitory effect of Sambiloto (Andrographis paniculata Nees) leaf extract on growth of Candida albicans

Lambang Bargowo 1, *, Irma Josefina Savitri 1, Dewi Nur Aini 2, Alfarabi Anhar 2 and Viriya Paramita Devi 2

1 Department of Periodontology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
2 Dental Medicine Education Study Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
 
Research Article
World Journal of Advanced Research and Reviews, 2023, 20(03), 752-758
Article DOI: 10.30574/wjarr.2023.20.3.2521
DOI url: https://doi.org/10.30574/wjarr.2023.20.3.2521
 
Received on 31 October 2023; revised on 09 December 2023; accepted on 11 December 2023
 
Background: Linear gingival erythema (LGE) is a periodontal disease caused by fungal infection of the genus Candida. Based on the results of Nugraha’s research, the most common Candida species in LGE was Candida albicans which reached 71.43%. Several studies have shown that sambiloto (Andrographis paniculata Nees) has antifungal activity because sambiloto contains active ingredients such as andrographolides, flavonoids, alkaloids, saponins, and tannins.
Objective: This study aims to determine the inhibitory effect of sambiloto (Andrographis paniculata Nees) leaf extract on growth of Candida albicans.
Methods: This research is an in-vitro laboratory experimental study. Sambiloto (Andrographis paniculata Nees) leaf extract was produced by the maceration method using 70% ethanol. The inhibition testing on Candida albicans cultures was carried out by spectrophotometric methods and colony counts.
Result: At concentration of 100%, 50%, 25%, and 12.5% of sambiloto leaf extract, no fungal colonies were found. While at concentration of 6.25% can inhibit fungal by 91.67%. Statistical tests on each concentration group showed a significance value of 0,001 (p<0.05).
Conclusion: Sambiloto (Andrographis paniculata Nees) leaf extract has an inhibitory effect on growth of Candida albicans with MIC values at concentration of 6.125% and MBC of 12.5%.
 
Sambiloto (Andrographis paniculata Nees); Candida albicans; Inhibitory effect; Spectrophotometry; Colony counts.
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2023-2521.pdf

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Lambang Bargowo, Irma Josefina Savitri, Dewi Nur Aini, Alfarabi Anhar and Viriya Paramita Devi. The inhibitory effect of Sambiloto (Andrographis paniculata Nees) leaf extract on growth of Candida albicans. World Journal of Advanced Research and Reviews, 2023, 20(3), 752-758. Article DOI: https://doi.org/10.30574/wjarr.2023.20.3.2521

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