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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in April 2026 (Volume 30, Issue 1) Submit manuscript

Systematic review of case reports of neutropenic enterocolitis in children with hematologic malignancies

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  • Systematic review of case reports of neutropenic enterocolitis in children with hematologic malignancies

Rizki Fajar Muhammad 1, Alpha Fardah Athiyyah 2, * and Ariandi Setiawan 3

1 Medical Program, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia.
2 Department of Pediatrics, Universitas Airlangga, Surabaya, East Java, Indonesia.
3 Department of Pediatrics Surgery, Universitas Airlangga, Surabaya, East Java, Indonesia.
 
Review Article
World Journal of Advanced Research and Reviews, 2023, 20(02), 942-952
Article DOI: 10.30574/wjarr.2023.20.2.2230
DOI url: https://doi.org/10.30574/wjarr.2023.20.2.2230
 
Received on 23 September 2023; revised on 06 November 2023; accepted on 08 November 2023
 
Neutropenic Enterocolitis (NE) is a gastrointestinal disease that is a quite rare disease but life threatening and one of the primary cause of mortality, NE predominantly affect immunocompromised children. Pediatric malignancies, specifically pediatric leukemia, are one of the primary causes of mortality. Leukemias, including Acute Lymphoblastic Leukemia (ALL), Acute Myeloblastic Leukemia (AML), and Chronic Myeloblastic Leukemia (CML), are a substantial component of juvenile cancers. Of these, ALL is the most common, with the highest occurrence between the ages of 2 and 5. Chemotherapy is the major treatment for juvenile leukemia and has been successful in obtaining survival rates of above 90%. Nevertheless, there are consequences associated with it, such as Neutropenic Enterocolitis (NE).   Neutropenic patients may get Necrotizing Enterocolitis (NEC), which can occur when bacteria pass through the weakened intestinal lining as a result of chemotherapy. Common symptoms of this condition encompass stomach pain, diarrhea, and neutropenia, while severe complications may involve sepsis and gastrointestinal hemorrhage.   Early detection and comprehension are crucial due to the non-specific nature of its presentation. Further emphasize the importance of NE management in the field of pediatric oncology.
 
Leukemia; Neutropenic Enterocolitis; Pediatric; Chemotherapy; Typhlitis
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2023-2230.pdf

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Rizki Fajar Muhammad, Alpha Fardah Athiyyah and Ariandi Setiawan. Systematic review of case reports of neutropenic enterocolitis in children with hematologic malignancies. World Journal of Advanced Research and Reviews, 2023, 20(2), 942-952. Article DOI: https://doi.org/10.30574/wjarr.2023.20.2.2230

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