1 Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
2 Division of Neurobehaviour, Department of Neurology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
3 Dr. Sardjito Hospital Yogyakarta, Yogyakarta, Indonesia.
Research Article
World Journal of Advanced Research and Reviews, 2023, 19(02), 553–567
Received on 21 June 2023; revised on 08 August 2023; accepted on 10 August 2023
Objectives: Cognitive function gradually deteriorating over time is a symptom of dementia. Increased delta and theta slow wave activity is associated with decreased cognitive function. The study aimed to determine the effect of oral nutritional supplementation containing phosphatidylserine, choline, and uridine on improving cognitive function and quantitative electroencephalographic features in older people with mild-moderate dementia.
Method: A pre-experimental study with the design of one groups pretest-posttest at Dr. Radjiman Wediodiningrat Malang's psychogeriatric clinic from January to March 2020. A total research subjects were 19. Oral nutritional supplementation containing phosphatidylserine, choline, and uridine in milk is given for four weeks. Laboratory and cognitive function tests using MMSE and MoCA-Ina scores and QEEG examinations were performed before and after supplementation.
Results: The MMSE and MoCA-Ina scores showed improved cognitive function after four weeks of supplementation with p<0.000 and p<0.000, respectively. The QEEG picture before supplementation showed that from 19 subjects, hyperactivity was obtained from the slow wave type, namely Delta waves (0.1-4 Hz) and theta (4-8 Hz), namely 63.16% and 89.47% of subjects. After supplementation, there was a decrease in hyperactivity to 31.58% and 47.37% with a significance of 0.006 and 0.003 (p<0.05), so it was concluded that there was a significant difference in the appearance of delta and theta waves on QEEG examination.
Conclusion: Oral nutritional supplementation containing phosphatidylserine, choline, and uridine showed improvement in cognitive function, and quantitative electroencephalograph showed a significant difference in changes in delta and theta wave hyperactivity that affected attention improvement in cognitive domains of dementia subjects.
Phosphatidylserine Supplementation; Choline; Uridine; Cognitive Function; Dementia; QEEG
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Yunita Christiandari, I Dewa Putu Pramantara, Probosuseno and Astuti. Effect of Oral Nutrition Supplementation (ONS) contains phosphatidylserine, choline, and uridine on cognitive function and quantitative electroencephalography in elderly patients with mild and moderate dementia. World Journal of Advanced Research and Reviews, 2023, 19(2), 553-567. Article DOI: https://doi.org/10.30574/wjarr.2023.19.2.1582