Home
World Journal of Advanced Research and Reviews
International Journal with High Impact Factor for fast publication of Research and Review articles

Main navigation

  • Home
    • Journal Information
    • Editorial Board Members
    • Reviewer Panel
    • Abstracting and Indexing
    • Journal Policies
    • Our CrossMark Policy
    • Publication Ethics
    • Issue in Progress
    • Current Issue
    • Past Issues
    • Instructions for Authors
    • Article processing fee
    • Track Manuscript Status
    • Get Publication Certificate
    • Join Editorial Board
    • Join Reviewer Panel
  • Contact us
  • Downloads

eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in March 2026 (Volume 29, Issue 3) Submit manuscript

A case report on BPDCN: Blastic Plasmacytoid Dendritic Cell Neoplasm

Breadcrumb

  • Home
  • A case report on BPDCN: Blastic Plasmacytoid Dendritic Cell Neoplasm

Mercy Paul M 1, * and Sukumar Naidu KD 2, *

1 APGDCR, Clinical Research, Visakhapatnam, Andhra Pradesh, India.
2 APGDCR, IPCCR (NIH), Clinical Research, Visakhapatnam, Andhra Pradesh, India.
 
Case Study
World Journal of Advanced Research and Reviews, 2023, 19(02), 091-098
Article DOI: 10.30574/wjarr.2023.19.2.1469
DOI url: https://doi.org/10.30574/wjarr.2023.19.2.1469
 
Received on 12 June 2023; revised on 26 July 2023; accepted on 28 July 2023
 
Dendritic cells are present in both lymphoid and non-lymphoid organs, which are heterogenous group of nonphagocytic and nonlymphoid immune accessory cells. Plasmacytoid dendritic cell (which has an eccentric nuclei) are subset of dendritic cells aid in secreting high levels of type 1 interferons by activation and gaining dendritic cell like morphology, play an important role in antiviral immunity and are involved in initiation and development stages of inflammatory response. The initial presentation of extra-cutaneous region is an involvement of regional lymph nodes later progressed to bone marrow and peripheral blood. When bone marrow is extensively involved, neoplastic cells interfere peripheral blood resembling as circulating leukemic myeloid or lymphoid blasts. BPDCN is confused with cutaneous peripheral T-cell lymphoma due to cutaneous involvement. Comparative to adults, BPDCN in children are less aggressive. Intensive 1st line therapy along with “Lymphoid type” chemotherapy show better results. Lymphodenopathy, splenomegaly, bone marrow involvement and cytopenia, cutaneous lesions are observed widely.
 
Plasmacytoid dendritic cells (pDCs); Acute myeloid leukemia (AML); Flow cytometry; Chemotherapy; Mutation; Bone marrow
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2023-1469.pdf

Preview Article PDF

Mercy Paul M and Sukumar Naidu KD. A case report on BPDCN: Blastic Plasmacytoid Dendritic Cell Neoplasm. World Journal of Advanced Research and Reviews, 2023, 19(2), 091-098. Article DOI: https://doi.org/10.30574/wjarr.2023.19.2.1469

Copyright © Author(s). All rights reserved. This article is published under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits use, sharing, adaptation, distribution, and reproduction in any medium or format, as long as appropriate credit is given to the original author(s) and source, a link to the license is provided, and any changes made are indicated.

All statements, opinions, and data contained in this publication are solely those of the individual author(s) and contributor(s). The journal, editors, reviewers, and publisher disclaim any responsibility or liability for the content, including accuracy, completeness, or any consequences arising from its use.

Get Certificates

Get Publication Certificate

Download LoA

Check Corssref DOI details

Issue details

Issue Cover Page

Editorial Board

Table of content

Copyright © 2026 World Journal of Advanced Research and Reviews - All rights reserved

Developed & Designed by VS Infosolution