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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in March 2026 (Volume 29, Issue 3) Submit manuscript

Pulmonary and cerebral leukostasis as an unusual case in a patient with chronic leukemia in chronic phase: Case report and literature review

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  • Pulmonary and cerebral leukostasis as an unusual case in a patient with chronic leukemia in chronic phase: Case report and literature review

Diana Margarita Otero de la Hoz 1, Wilver Arley Mosquera Vanegas 2, Laura Isabel Acosta Galíndez 2, *, Ismael Arango Herrera 2 and Juan Luis Echeverri Ospina 2

1 Department of Hematology, Centro Oncológico Antioquia, Medellín, Antioquia, Colombia.
2 Department of Intensive Care Medicine, Centro Oncológico Antioquia, Medellín, Antioquia, Colombia.
 
Case Study
World Journal of Advanced Research and Reviews, 2023, 19(01), 1120-1125
Article DOI: 10.30574/wjarr.2023.19.1.1360
DOI url: https://doi.org/10.30574/wjarr.2023.19.1.1360
 
Received on 29 May 2023; revised on 17 July 2023; accepted on 19 July 2023
 
Hyperleukocytosis is defined as an absolute white blood cells count greater than 100.000cel/ml, being more common in acute myeloid leukemia (AML) than in chronic myeloid leukemia (CML). CML is the predominance of mature granulocytes, its main manifestation is hyperleukocytosis, that can increase the risk of pulmonary and cerebral leukostasis; although this event is uncommon in patients with CML in chronic phase. We present the case of a 38-year old male who presents with hyperleukocytosis that progress to hypoxemic respiratory failure and multiple intracerebral hemorrhage, treated with cytoreduction and tyrosine kinase inhibitors; without leukapheresis, with appropriate clinical evolution. Leukostasis is a high mortality complication that should be considered in patients with hyperleukocytosis who presents with neurological or respiratory distress, and constitutes a medical emergency in which treatment can’t be delayed.
 
Leukemia; Hyperleukocytosis; Leukostasis; Cerebral leukostasis; Pulmonary leukostasis
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2023-1360.pdf

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Diana Margarita Otero de la Hoz, Wilver Arley Mosquera Vanegas, Laura Isabel Acosta Galíndez, Ismael Arango Herrera and Juan Luis Echeverri Ospina. Pulmonary and cerebral leukostasis as an unusual case in a patient with chronic leukemia in chronic phase: Case report and literature review. World Journal of Advanced Research and Reviews, 2023, 19(1), 1120-1125. Article DOI: https://doi.org/10.30574/wjarr.2023.19.1.1360

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