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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in April 2026 (Volume 30, Issue 1) Submit manuscript

Application of chitosan-gelatin-carbonate hydroxy apatite scaffold toward the number of osteoblasts in alveolar bone defects in Wistar Rats

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  • Application of chitosan-gelatin-carbonate hydroxy apatite scaffold toward the number of osteoblasts in alveolar bone defects in Wistar Rats

Devi Rianti 1, *, Noor Zain Salsabilla Prabowo 2, Maryama Aflaha 2, Titien Hary Agustantina 1 and Adriansyah syahrom

1 Department of Dental Materials, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
2 Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
3 Medical Devices and Technology Centre (MEDITEC), Institute of Human Centered and Engineering (iHumEn), University Teknologi, Malaysia, 81310 UTM Skudai, Johor, Malaysia.
 
Research Article
World Journal of Advanced Research and Reviews, 2023, 18(03), 768-775
Article DOI: 10.30574/wjarr.2023.18.3.0840
DOI url: https://doi.org/10.30574/wjarr.2023.18.3.0840
 
Received on 29 March 2023; revised on 09 June 2023; accepted on 12 June 2023
 
Tooth extraction may cause bone defects that require regenerative therapy. Chitosan, gelatin, and carbonate hydroxyapatite can help increase osteoblast proliferation and differentiation, which plays a role in the bone regeneration process. Scaffold made from chitosan-gelatin carbonate hydroxyapatite has promising characteristics that may help enhance the bone regeneration process. This study aimed to determine the effect of chitosan-gelatin carbonate hydroxyapatite (CG:CHA) scaffold application towards the number of osteoblasts on alveolar bone defect in Wistar rats after tooth extraction. In vivo experimental laboratory research conducted with post-test-only control group design. The Wistar rats were divided into 6 groups, tooth extraction was conducted, and in the treatment group the C-G:CHA scaffold was applied on the sockets afterward. After 7, 14, and 21 days of scaffold application, jaw resection was done to observe the number of osteoblasts by HE histological examination. The result data were analyzed using a one-way ANOVA test. Data analysis using one-way ANOVA test results in P=0 (P <0,05) which indicates a significant difference between the control and treatment groups. The chitosan-gelatin carbonate hydroxyapatite (C-G:CHA) scaffold can increase the number of osteoblasts.
 
Scaffold; Chitosan; Gelatin; Carbonate hydroxyapatite; Osteoblast; Medicine
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2023-0840.pdf

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Devi Rianti, Noor Zain Salsabilla Prabowo, Maryama Aflaha, Titien Hary Agustantina and Adriansyah syahrom. Application of chitosan-gelatin-carbonate hydroxy apatite scaffold toward the number of osteoblasts in alveolar bone defects in Wistar Rats. World Journal of Advanced Research and Reviews, 2023, 18(3), 768-775. Article DOI: https://doi.org/10.30574/wjarr.2023.18.3.0840

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