Department of Biochemistry, Laboratory of Pharmacology and Toxicology, Faculty of Science, University of Yaoundé I, PO Box 812 Yaoundé, Cameroon.
Research Article
World Journal of Advanced Research and Reviews, 2023, 18(02), 329–337
Article DOI: 10.30574/wjarr.2023.18.2.0777
Received on 19 March 2023; revised on 03 May 2023; accepted on 06 May 2023
Erectile dysfunction is a major public health problem leading to harmful consequences for couples. Hence the need to find adequate treatments using medicinal plants such as Pycnanthus angolensis, a Cameroonian plant used to treat erectile dysfunction. The effects of aqueous extract of Pycnanthus angolensis wood were evaluated on male rat sexual behavior and nitric oxide release. Adult male Wistar rats were divided into 4 groups of 5 each that included a group receiving orally: distilled water (10 ml/Kg BW), plant extract treatment (43 or 86 or 172 mg/kg BW). Sexual behaviors were monitored on days 1, 4, 7, and 14 by pairing male rats to receptive females and nitric oxide levels were assessed in penile homogenate. At the end of the 14 days of treatment, rats were killed and sexual organs weighed. No significant effect was observed on sexual organs weights. When administered at a dose of 43 mg/Kg, body weight; the plant extract significantly increased (p<0.05) the sexual performance as well as the libido of male rats. Nitric oxide release was significantly increased (p<0.05) in that group of extract-treated rats, while compared to the control group. The study demonstrates that Pycnanthus angolensis is a medicinal plant which can enhance the sexual behaviors of male rat. Hence, it can be used for the management of erectile dysfunction, mainly at a dose of 43 mg/Kg, body weight.
Pycnanthus angolensis; Aqueous extract; Sexual behavior; Nitric oxide release
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Sara Nathalie Edjenguèlè Béboy, Louise Marie Coûte-Chère Mbog, Yannick Sani Jignoua, Paulin Teko Keumedjio, Patrick Kevin Motto Feune and Paul Fewou Moundipa. Effects of the aqueous extract of Pycnanthus angolensis (Myristicaceae) on male rat sexual behavior and nitric oxide release. World Journal of Advanced Research and Reviews, 2023, 18(2), 329-337. Article DOI: https://doi.org/10.30574/wjarr.2023.18.2.0777