Electrospinning-modified Pt/CeO2 nano bandage as a promising therapy to reduce secondary brain injury

Alfiani Zukhruful Fitri Rifa’i 1, Rizqi Apsari Fairuz Kamila 1, * and Clara Alverina 1, Reny I’tishom 2, *

1 Medical Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
2 Department of Biomedical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
 
Review Article
World Journal of Advanced Research and Reviews, 2022, 13(01), 298–304
Article DOI: 10.30574/wjarr.2022.13.1.0771
 
Publication history: 
Received on 30 November 2021; revised on 09 January 2022; accepted on 11 January 2022
 
Abstract: 
Traumatic brain injury (TBI) continues to be a major contributor to morbidity, disability, and mortality in all age groups. Initial brain damage is accompanied by acute and irreversible primary damage to the parenchyma, while subsequent secondary brain damage often progresses slowly over months to years, thus providing a window for therapeutic intervention. The most frequent case which happened is excessive oxidative stress and calcium release after brain injury. Although some traditional antioxidants have been clinically approved, the efficacy is far from satisfactory due to their low ROS-scavenging efficiency, instability, toxicity, or inadequate penetration of the blood-brain barrier. Moreover, the combination of Nanozyme based-bandage with Pt/CeO2 atom catalysis with electrospinning nanofibers N-type voltage-gated calcium channel blocker (SNX-185) is predicted to be as promising as a potential novel to reduce secondary injury of TBI. Therefore, the duo could cut down morbidity and mortality rates because of TBI in the future, noninvasively. 
 
Keywords: 
Traumatic brain injury; Secondary Injury; Nanozymes; SNX-185; Electrospinning nanofiber
 
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Copyright information: 
Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0

 

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