1 Department of Obstetrics and Gynaecology, Rivers State University Teaching Hospital, 6-8 Harley Street, Old G.R.A, Port-Harcourt, Nigeria.
2 Department of Obstetrics and Gynaecology, University of Port-Harcourt Teaching Hospital, Choba, Port-Harcourt, Nigeria.
Research Article
World Journal of Advanced Research and Reviews, 2023, 17(01), 162-172
Article DOI: 10.30574/wjarr.2023.17.1.1470
Received on 22 November 2022; revised on 04 January 2023; accepted on 06 January 2023
Background: Preeclampsia is a multi-system disorder of pregnancy. It is associated with a significantly increased risk of maternal and fetal morbidity and mortality. Oxidative stress has been implicated. Selenium is a very important trace element in the synthesis of endogenous antioxidants which help to balance the effects of oxidative free radicals. This study sought to determine the relationship between serum selenium deficiency and preeclampsia among pregnant women.
Method: A prospective case-control study was carried out on consenting preeclamptic (135) and normotensive (135) pregnant women in their second half of pregnancy. Blood samples were taken for serum selenium estimation and analyzed using Atomic Absorption Spectrophotometry (AAS). Their Socio-demographic information was collected through a structured proforma. Data were analyzed using SPSS version 20. A P-value of < 0.05 was considered to be statistically significant.
Results: There was no significant difference in characteristics between the two groups. The mean selenium level of the preeclamptic women (0.52 ± 0.31µmol/l) was significantly (P=0.001) lower than that of the normotensive women (0.73 ± 0.24µmol/l). Bivariate analysis showed that preeclamptic women were 3.6 times more likely to have a deficiency in selenium compared to normotensive women (OR=3.61; P=0.001; 95%CI: 2.13-6.10). No significant difference was noted in the serum level of selenium in patients with mild versus severe preeclampsia.
Conclusion: This study showed that pregnant women with selenium deficiency were 3.6 times more likely to develop preeclampsia compared to healthy normotensive pregnant women. However, there was no significant difference between levels in mild compared to severe preeclamptic women.
Preeclampsia; Selenium deficiency; Trace elements; Antioxidants
Preview Article PDF
Chinweowa Ohaka, Samuel A Uzoigwe, Esther Ijeoma Nonye-Enyidah, Peter Abiye. Awoyesuku, Bapakaye Ngeri, Awopola Ibiebelem. Jumbo and Simeon Chijioke Amadi. Relationship between serum selenium deficiency and preeclampsia among pregnant women at the Rivers State university teaching hospital, Port Harcourt, Nigeria. World Journal of Advanced Research and Reviews, 2023, 17(1), 162-172. Article DOI: https://doi.org/10.30574/wjarr.2023.17.1.1470