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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in March 2026 (Volume 29, Issue 3) Submit manuscript

TNF-α, TNF-R1, TNF-R2 levels in women with normal pregnancy, preeclampsia, and preeclampsia with sepsis

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  • TNF-α, TNF-R1, TNF-R2 levels in women with normal pregnancy, preeclampsia, and preeclampsia with sepsis

Mira Kusuma Wardhani *

Health Science, Faculty of Medicine, University of Wijaya Kusuma Surabaya, Surabaya, Indonesia.
 
Research Article
World Journal of Advanced Research and Reviews, 2022, 15(03), 358-365
Article DOI: 10.30574/wjarr.2022.15.3.0948
DOI url: https://doi.org/10.30574/wjarr.2022.15.3.0948
 
Received on 17 August 2022; revised on 21 September 2022; accepted on 23 September 2022
 
Preeclampsia (PE) is a disorder in pregnancy with a worldwide prevalence of about 5-8% of cases. TNF is the main physiological mediator of the inflammatory process. These membrane-bound and soluble cytokines are biologically active. They have different affinities for two types of TNF receptors, apoptotic receptors (TNFR1) and non-apoptotic receptors (TNFR2). This study reveals the levels of TNF-α, TNF-R1, TNF-R2 in women with normal pregnancy, preeclampsia, and preeclampsia with sepsis. An observational analytic cross sectional research design is applied. The minimum number of sample is 14 women for each group (group 1: women with normal pregnancy, group 2: preeclampsia, and group 3: preeclampsia with sepsis). The results show that
·         There is an increase in TNF- levels in preeclamptic women and in preeclamptic women with sepsis
·         There is an increase in TNF-R1 receptor levels in preeclamptic women and in preeclamptic women with sepsis
There is an increase in TNF-R2 receptor levels in preeclamptic women and in preeclamptic women with sepsis.
 
TNF level; Women; Preeclampsia; Preeclampsia with sepsis
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2022-0948.pdf

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Mira Kusuma Wardhani. TNF-α, TNF-R1, TNF-R2 levels in women with normal pregnancy, preeclampsia, and preeclampsia with sepsis. World Journal of Advanced Research and Reviews, 2022, 15(3), 358-365. Article DOI: https://doi.org/10.30574/wjarr.2022.15.3.0948

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