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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in March 2026 (Volume 29, Issue 3) Submit manuscript

A validated stability indicating RP-HPLC method for the determination of molnupiravir in pharmaceutical dosage form

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  • A validated stability indicating RP-HPLC method for the determination of molnupiravir in pharmaceutical dosage form

M. Bindu 1, Kumaraswamy Gandla 2, *, Swapna Vemireddy 3, Sashmitha Samuel 4 and Yalamanchili Praharsha 4

1 Department of Pharmaceutical Analysis,Marri Laxman Reddy institute of Pharmacy, Hyderabad, Telangana state, India.
2 Chaitanya University, Department of Pharmacy, Hanumkonda, Telangana, India.
3 Vision college of pharmaceutical sciences and research,Boduppal, Hyderabad, India.
4 Marri Laxman Reddy institute of Pharmacy, Hyderabad, Telangana state, India.
 
Research Article
World Journal of Advanced Research and Reviews, 2022, 15(01), 580-590
Article DOI: 10.30574/wjarr.2022.15.1.0720
DOI url: https://doi.org/10.30574/wjarr.2022.15.1.0720
 
Received on 15 June 2022; revised on 20 July 2022; accepted on 22 July 2022
 
A simple, Precise, Accurate method was developed for the estimation of Molnupiravirby RP-HPLC technique. Chromatographic conditions used are stationary phase Agilent C18 (250 mm*4.6mm3.6m), Mobile phase Orthophopoaricacid: Acetonitrile in the ratio of 60:40 and flow rate was maintained at 1.0 mL/min, detection wave length was 254 nm, column temperature was set to 30o C and diluent was mobile phase Conditions were finalized as optimized method. System suitability parameters were studied by injecting the standard six times and results were well under the acceptance criteria. The retention time for Molnupiravir was 2.46 min. The method was validated for linearity, accuracy, precision, specificity, limit of detection, limit of quantification and robustness. Limit of detection and limit of quantification were found 0.06 μg/ml and 0.21 μg/ml respectively and recovery of Molnupiravir from tablet formulation was found 99.73%. The proposed method was successfully applied for the quantitative determination of Molnupiravir in tablet formulation.
 
HPLC; Molnupiravir; Method development; Method validation; Degradation studies ICH Guidelines
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2022-0720.pdf

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M. Bindu, Kumaraswamy Gandla, Swapna Vemireddy, Sashmitha Samuel and Yalamanchili Praharsha. A validated stability indicating RP-HPLC method for the determination of molnupiravir in pharmaceutical dosage form. World Journal of Advanced Research and Reviews, 2022, 15(1), 580-590. Article DOI: https://doi.org/10.30574/wjarr.2022.15.1.0720

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