Neuroprotective potential of paddy rice: Advancing nutritional and therapeutic strategies for brain health
Saikrupa Institute of pharmacy, Ghargaon, Shrigonda, A. nagar, Maharashtra, India 413728.
Review Article
World Journal of Advanced Research and Reviews, 2024, 24(02), 2440–2453
Article DOI: 10.30574/wjarr.2024.24.2.3587
Publication history:
Received on 16 October 2024; revised on 23 November 2024; accepted on 26 November 2024
Abstract:
Paddy rice has gained attention beyond its role as a staple food, now recognized for its neuroprotective properties due to its rich phytochemical content. Compounds like tocotrienols, gamma-oryzanol, and phenolic acids in paddy rice exhibit antioxidant, anti-inflammatory, and neuroregenerative properties. These compounds help reduce oxidative stress, manage neuroinflammation, balance neurotransmitter function, and promote neurogenesis, supporting overall brain health and potentially delaying neurodegenerative processes. Components like gamma-oryzanol and ferulic acid show promise in decreasing neuroinflammation and enhancing dopaminergic function, suggesting therapeutic potential for conditions like Parkinson's and Alzheimer's. Research indicates paddy rice bioactives can improve cognitive function and neural resilience, underscoring their therapeutic value for neurological disorders. Further studies are required to validate these findings in clinical settings, explore optimal dosages, and enhance bioavailability. This review summarizes recent research, highlighting the promising effects of paddy rice-derived nutraceuticals and emphasizing the importance of bridging lab discoveries with practical medical applications through comprehensive research efforts.
Keywords:
Paddy rice; Neuroprotection; Antioxidants; Neuroinflammation; Cognitive health; Neurological disorders
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0