Oral mucoadhesive drug delivery system: Formulation strategies and evaluation techniques
Tilak Maharashtra Vidyapeeth’s Lokmanya Tilak Institute of Pharmacy, Kharghar, Navi Mumbai Maharashtra, India.
Review Article
World Journal of Advanced Research and Reviews, 2024, 24(01), 1706–1719
Publication history:
Received on 05 September 2024; revised on 17 October 2024; accepted on 19 October 2024
Abstract:
Mucoadhesive drug delivery systems (MDDS) represent an innovative method for administering drugs through oral routes such as the buccal, sublingual, and gingival areas. These systems leverage natural or synthetic polymers to ensure prolonged adherence to mucosal surfaces, enabling extended and controlled release of medication. Several factors influence the effectiveness of mucoadhesion, including the hydrophilicity of polymers, molecular weight, and environmental factors like pH and moisture levels. MDDS can take various forms, including tablets, films, patches, lozenges, and gels, each offering different drug release profiles such as immediate, sustained, or controlled. These systems enhance drug bioavailability by avoiding first-pass metabolism, making them particularly beneficial for medications with low oral bioavailability or those requiring targeted delivery. Although MDDS offer improved patient compliance and therapeutic effectiveness, they still face challenges like irritation, taste concerns, and the diluting effect of saliva, which can impact drug stability. Despite these challenges, MDDS hold significant promise for advancing drug delivery technologies across various medical applications. This review thoroughly examines the mechanisms, advantages, limitations, and future prospects of mucoadhesive drug delivery systems.
Keywords:
Mucoadhesive Drug Delivery Systems; Oral Mucosal Delivery; Buccal Patches; Drug Bioavailability; Controlled Release; Polymer-Based Drug Delivery.
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0