Impacts of aqueous extracts of Annona senegalensis and Hallea ledermannii on hematological parameters in Wistar rats made diabetic by alloxan induction.
1 UFR Agroforestery, Agrovalorisation Laboratory, University Jean Lorougnon Guédé, BP 150 Daloa, Ivory Coast.
2 UFR Biological Sciences, Animal Biology Department, University Péléferon Gon Coulibaly, BP 1328 Korhogo, Ivory Coast.
3 UFR Biosciences, Biology and Health Laboratory, University Félix Houphouët Boigny, 22 BP 582 Abidjan 22, Ivory Coast.
Research Article
World Journal of Advanced Research and Reviews, 2024, 23(03), 1156–1166
Publication history:
Received on 18 June 2024; revised on 04 September 2024; accepted on 06 September 2024
Abstract:
Background: The costly treatment of diabetes mellitus is leading low-income populations to turn to phytotherapy, which requires preclinical testing to prevent dangerous side effects.
Objective: To evaluate the impact of aqueous extracts of Annona senegalensis (EAAs) and Hallea ledermannii (EAHl) on the haematological parameters of diabetic Wistar rats.
Material and methods: Diabetes was induced in normal rats by injection of alloxane. Diabetic rats were treated with the test substances for four (4) and thirteen (13) weeks. Haematological parameters were assayed after these treatments.
Results: Significantly, after four (4) weeks of treatment, platelet values increased by (49.54%) in animals treated with EAAs100. White blood cell count increased by 41.12% and 60.66% in rats treated with EAHl200.
After 13 weeks, in rats treated with EAHl400, an 84.32% increase (p<0.05) in platelets was observed. Neutrophil counts were statistically reduced by 34.92%, 53.97%, 49.21% and 53.97% respectively in diabetic rats treated with Gli10, EAAs100, EAAs200 and EAHl400, all compared with untreated diabetic rats.
Conclusion: This study showed that EAAs and EAHl have the capacity to fight infections in the body by helping to regulate haematological parameters.
Keywords:
Annona Senegalensis; Hallea ledermannii; Glibenclamide; Hematology; Rats; Diabetes.
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