A meta-analysis study on colistin resistance in Acinetobacter baumannii species in Turkey
1 Department of Microbiology and Clinical Microbiology Laboratory, Training and Research Hospital, Health Sciences University Turkey, Ilkadım, Samsun, Turkey.
2 Department of Clinical Microbiology and Infectious Diseases, Gazi State Hospital, Ministry of Health, Ilkadım, Samsun, Turkey.
3 Department of Microbiology and Clinical Microbiology Laboratory, Şehit Prof. Dr İlhan Varank Training and Research Hospital, Health Sciences University, Sancaktepe, İstanbul, Turkey.
Research Article
World Journal of Advanced Research and Reviews, 2021, 10(02), 090–097
Article DOI: 10.30574/wjarr.2021.10.2.0180
Publication history:
Received on 19 March 2021; revised on 30 April 2021; accepted on 03 May 2021
Abstract:
Aim: Acinetobacter baumannii is a nosocomial infectious agent that may be resistant to several antimicrobial drugs, including colistin. Colistin is a crucial antimicrobial agent in resistant A. baumannii infections. Colistin resistance varies between countries and regions worldwide. This study aimed to evaluate the studies on colistin resistance of A. baumannii strains in different regions of Turkey, show the increasing colistin resistance in years, and discuss the solution suggestions.
Methods: The online electronic database was searched for studies evaluating the antibacterial efficacy of colistin combined with other antibiotics or alone in clinical samples of patients with A. baumannii infection.
Results: In our study, colistin susceptibility was found to be between 81.8%-100% in Turkey. The lowest susceptibility to colistin for A. baumannii strains was reported in the Aegean Region (81.8-100%), followed by Black Sea (82.4-100%), Southeast Anatolia (94-96%), Central Anatolia (95.8-100), Marmara (96.8-100%), Mediterranean (98-100%), respectively, and the highest susceptibility was found in Eastern Anatolia Region (98.6-100%). According to the studies, a partial decrease in colistin sensitivity was found in some regions over the years and more decrease in others, but this decrease was not statistically significant (p> 0.05). The cities with the lowest colistin susceptibility were reported as İzmir 81.8%, Samsun 82.4%, Diyarbakır 94%, Düzce 94.1% and Ankara 95.8%.
Conclusion: Colistin is still the most effective antimicrobial drug in A. baumannii infections. Our study concluded that there were some differences between regions and even within the same region in colistin susceptibility of A. baumannii in Turkey, and resistance development has increased over the years.
Keywords:
Acinetobacter baumannii; Colistin; Resistance distribution
Full text article in PDF:
Copyright information:
Copyright © 2021 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0