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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in April 2026 (Volume 30, Issue 1) Submit manuscript

Plasma levels of obestatin and ghrelin and obestatin/ghrelin ratio in obese patients

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  • Plasma levels of obestatin and ghrelin and obestatin/ghrelin ratio in obese patients

Myriam Sfar 1, Houda Ben Jemaa 2, *, Amani Kallel 3, Kamel Ben-Mahrez 1, Moncef Feki 3 and Fethi Ben Slama 1, 2

1 Laboratory of Biochemistry and Biotechnology LR01ES05, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia.
2 Higher School of Health Sciences and Technics, University of Tunis El Manar, Tunis, Tunisia.
3 Department of Endocrinology, Rabta Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
 
Research Article
World Journal of Advanced Research and Reviews, 2022, 14(01), 336-341
Article DOI: 10.30574/wjarr.2022.14.1.0320
DOI url: https://doi.org/10.30574/wjarr.2022.14.1.0320
 
Received on 08 March 2022; revised on 14 April 2022; accepted on 16 April 2022
 
Background: Obestatin and ghrelin are two gastric hormones that have a potential role in dietary intake regulation. Obestatin/ghrelin ratio has been proposed as activity markers in obesity. The study aimed to evaluate ghrelin, obestatin and the ghrelin/obestatin ratio in obese compared to control subjects and to determine their relationship with anthropometric and metabolic parameters.
Methods: Fasting obestatin and ghrelin levels were measured using enzyme-linked immunosorbent assay ELISA in 28 obese and 24 healthy subjects. The fasting ghrelin/obestatin ratio was calculated. Anthropometric and metabolic parameters were also assessed.
Results: Obese patients had significantly lower obestatin and ghrelin blood levels compared with controls. The Ghrelin/Obestatin ratio was significantly lower in obese group 0.813±0.0417 ng/ml than in the control group 0.896±0.049 ng/ml, (p<0.001). In obese patients, obestatin and ghrelin were significantly and negatively correlated with BMI and positively correlated with HDL-C.
Conclusion: Circulating preprandial ghrelin to obestatin ratio is decreased obese subjects. We suggest that low preprandial ghrelin to obestatin ratio may be involved in the etiology and pathophysiology of obesity.
 
Obesity; Ghrelin; Obestatin; BMI and Lipid Parameters
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2022-0320.pdf

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Myriam Sfar, Houda Ben Jemaa, Amani Kallel, Kamel Ben-Mahrez, Moncef Feki and Fethi Ben Slama. Plasma levels of obestatin and ghrelin and obestatin/ghrelin ratio in obese patients. World Journal of Advanced Research and Reviews, 2022, 14(1), 336-341. Article DOI: https://doi.org/10.30574/wjarr.2022.14.1.0320

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