Antidepressant and nootropic activity of aqueous extract of Bougainvillea glabra
1 Faculty of Pharmacy, Pacific Academy of Higher Education and Research University, Udaipur, Rajsthan-313003.
2 Oriental College of Pharmacy, Sanpada, Navi Mumbai, Maharashtra-400705.
3 Pacific Academy of Higher Education and Research University, Udaipur, Rajsthan-313003.
4 Faculty of Pharmacy, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Churu Road, Vidyanagari, Churela, Rajasthan-333001.
Research Article
World Journal of Advanced Research and Reviews, 2021, 10(01), 334-339
Article DOI: 10.30574/wjarr.2021.10.1.0163
Publication history:
Received on 14 March 2021; revised on 23 April 2021; accepted on 26 April 2021
Abstract:
The aim of this analysis was to assess antidepressant & nootropic capacity of Bougainvillea Glabra aqueous extract (BGAE). Forced swim test, tail suspension test, & tetrabenazine mediated catalepsy & ptosis models were used to assess BGAE's antidepressant efficacy in mice at doses of 250 & 500 mg/kg orally. Morris water maze with elevated plus maze (EPM) was used to test nootropic behaviour. Normal medications for antidepressant & nootropic function were imipramine (25 mg/kg) & piracetam (300 mg/kg), respectively. Antioxidant assays such as DPPH & TBARS were used to validate antidepressant & nootropic function. When comparison to car, pre-treatment with BGAE resulted in substantial dose-dependent decrease in immobility time in both FST & TST. (P0.005) Tetrabenazine-induced catalepsy & ptosis were both decreased dramatically. Furthermore, in MWM & EPM, BGAE demonstrated dose-dependent cognitive enhancing behaviour. In DPPH assay, BGAE had IC50 of 17.39 g/ ml, & in TBARS assay, it had IC50 of 398.71 gm/ ml. BGAE has antidepressant & nootropic activities that are equivalent to imipramine & piracetam at doses of 250 & 500 mg/kg, respectively, which may be due to its effect on neurotransmitters & antioxidant function.
Keywords:
Depression; Nootropic activity; Bougainvillea Glabra; Antioxidant
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