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eISSN: 2582-8185 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in March 2026 (Volume 29, Issue 3) Submit manuscript

Diagnosis of thyroid malignancy using trace elements of nodular tissue determined by neutron activation analysis

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  • Diagnosis of thyroid malignancy using trace elements of nodular tissue determined by neutron activation analysis

Vladimir Zaichick *

Department of Radionuclide Diagnostics, Medical Radiological Research Centre, Obninsk, Russia.
 
Research Article
World Journal of Advanced Research and Reviews, 2022, 13(03), 438–450
Article DOI: 10.30574/wjarr.2022.13.3.0252
DOI url: https://doi.org/10.30574/wjarr.2022.13.3.0252
 
Received on 11 February 2022; revised on 22 March 2022; accepted on 24 March 2022
 
Thyroid benign (TBN) and malignant (TMN) nodules are a common thyroid lesion. The differentiation of TMN often remains a clinical challenge and further improvements of TMN diagnostic accuracy are warranted. The aim of present study was to evaluate possibilities of using differences in trace elements (TEs) contents in nodular tissue for diagnosis of thyroid malignancy. Contents of TEs such as silver (Ag), cobalt (Co), chromium (Cr), iron (Fe), mercury (Hg), iodine (I), rubidium (Rb), antimony (Sb), scandium (Sc), selenium (Se), and zinc (Zn) were prospectively evaluated in “normal” thyroid (NT) of 105 individuals as well as in nodular tissue of thyroids with TBN (79 patients) and to TMN (41 patients). Measurements were performed using non-destructive instrumental neutron activation analysis. It was observed that in TMN tissue the mean mass fraction of I was lower while the mean mass fraction of Rb was higher than in NT and TBN tissue. It was demonstrated that I content in nodular tissue is the most informative parameter for the diagnosis of thyroid malignancy. It was found that “Sensitivity”, “Specificity” and “Accuracy” of TMN identification using the I level in the needle biopsy of affected thyroid tissue was significantly higher than that using US examination and cytological test of fine needle aspiration biopsy. It was concluded that determination of the I level in a needle biopsy of TNs using non-destructive instrumental analytical method is a fast, reliable, and very informative diagnostic tool that can be successfully used as an additional test of thyroid malignancy identification.
 
Diagnosis of thyroid malignancy; Normal thyroid; Thyroid nodules; Trace elements; Neutron activation analysis
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2022-0252.pdf

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Vladimir Zaichick. Diagnosis of thyroid malignancy using trace elements of nodular tissue determined by neutron activation analysis. World Journal of Advanced Research and Reviews, 2022, 13(3), 438-450. Article DOI: https://doi.org/10.30574/wjarr.2022.13.3.0252

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