Evaluation of anti- inflammatory and analgesic activity of Bhasmas in experimental animal models
1 M Pharm student, SIMS College Of Pharmacy, Mangaldas Nagar, Guntur, India.
2 Associate Professor, SIMS College Of Pharmacy, Mangaldas Nagar, Guntur, India.
3 Professor, SIMS College Of Pharmacy, Mangaldas Nagar, Guntur, India.
Research Article
World Journal of Advanced Research and Reviews, 2024, 22(02), 832–847
Publication history:
Received on 02 April 2024; revised on 11 May 2024; accepted on 13 May 2024
Abstract:
Acute toxicity studies of both the bhasmas showed no mortality at 2000 mg/kg.The Scanning electron microscopy of both Tamra and Lauha bhasma indicated the nanomaterial characteristics which justifies claim of Ayurvedic bhasmas as ancient nanomaterials. Tamra and Lauha bhasma were found to be effective as anti-inflammatory agent in acute models of inflammation. It inhibits all phases of inflammation induced by carrageenan. Tamra and Lauha bhasma were found to be effective as anti-inflammatory agent in chronic model of inflammation. It significantly inhibits wet as well as dry weight of cotton pellet granuloma at highest doses only. Analgesic activity of both Tamra and Lauha bhasma in hot plate and tail immersion models were found to be significant at 120-240 mins.
Analgesic activity of both Tamra and Lauha bhasma in acetic acid models were found to be non-significant in nature, while found to be significant at late phase in formalin induced model. Tamra and Lauha bhasma also were found to have significant anti-arthritic activity in animal study.The whole pharmacological investigations were indicated that activity was only significant at therapeutic and more than therapeutic dose but nonsignificant at dose lower than therapeutic doses. The obtained results indicates the anti-inflammatory and analgesic potential of both these bhasmas probably by inhibiting inflammatory mediators.
Keywords:
Tamra; Lauha bhasm; Carrageenan; Ayurvedic; Inflammation
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