Uncommun presentation and clinicopathological features of Anaplasic pleomorphic Xanthoastrocytoma: A case report

Salma Abbas; EL Mehdi Hakkou; Mohammed Yassaad Oudrhiri; Adil Melhaoui; Nadia Cherradi; Hafsa El Ouazzani; Yasser ARKHA

doi:10.30574/wjarr.2026.30.1.1112

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Uncommun presentation and clinicopathological features of Anaplasic pleomorphic Xanthoastrocytoma: A case report

Salma Abbas ^{1, 3, *}, EL Mehdi Hakkou ^{1, 3}, Mohammed Yassaad Oudrhiri ^{1, 3}, Adil Melhaoui ^{1, 3}, Nadia Cherradi ^{2, 3}, Hafsa El Ouazzani ^{2, 3} and Yasser ARKHA ^{1, 3}

¹ Department of Neurosurgery HSR, Ibn Sina University Hospital Center in Rabat.
² Department of Pathology HSR, Ibn Sina University Hospital Center in Rabat.
³ Mohammed V University of Medicine and Pharmacy of Rabat Morocco.

Case Report

World Journal of Advanced Research and Reviews, 2026, 30(01), 2456-2461

Article DOI: 10.30574/wjarr.2026.30.1.1112

DOI url: https://doi.org/10.30574/wjarr.2026.30.1.1112

Publication history

Received on 17 March 2026; revised on 24 April 2026; accepted on 27 April 2026

Abstract

Background: Pleomorphic xanthoastrocytoma (PXA) is a rare primary tumor of the central nervous system. Anaplasia is defined by a mitotic index of 5 per 10 high-power fields and/or the presence of necrosis. Complete surgical excision and radiochemotherapy are recommended for this entity.
Case presentation: This is a 29-year-old woman with a one-month history of headaches and intracranial hypertension. Imaging revealed a large right basifrontal mass with a double fleshy component and a predominantly cystic appearance. Surgical excision was macroscopically complete. Immunohistological examination confirmed a pleomorphic anaplastic xanthoastrocytoma (grade 3; WHO, 2021).
Conclusions: We report this case to improve the understanding of the clinicoradiological, histopathological, and immunohistochemical features of this rarely encountered tumor.

Keywords

Anaplastic pleomorphic xanthoastrocytoma; Macroscopic total resection; Immunohistochemistry

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Salma Abbas, EL Mehdi Hakkou, Mohammed Yassaad Oudrhiri, Adil Melhaoui, Nadia Cherradi, Hafsa El Ouazzani and Yasser ARKHA. Uncommun presentation and clinicopathological features of Anaplasic pleomorphic Xanthoastrocytoma: A case report. World Journal of Advanced Research and Reviews, 2026, 30(01), 2456-2461. Article DOI: https://doi.org/10.30574/wjarr.2026.30.1.1112.

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Uncommun presentation and clinicopathological features of Anaplasic pleomorphic Xanthoastrocytoma: A case report

Salma Abbas ^{1, 3, *}, EL Mehdi Hakkou ^{1, 3}, Mohammed Yassaad Oudrhiri ^{1, 3}, Adil Melhaoui ^{1, 3}, Nadia Cherradi ^{2, 3}, Hafsa El Ouazzani ^{2, 3} and Yasser ARKHA ^{1, 3}

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Uncommun presentation and clinicopathological features of Anaplasic pleomorphic Xanthoastrocytoma: A case report

Salma Abbas 1, 3, *, EL Mehdi Hakkou 1, 3, Mohammed Yassaad Oudrhiri 1, 3, Adil Melhaoui 1, 3, Nadia Cherradi 2, 3, Hafsa El Ouazzani 2, 3 and Yasser ARKHA 1, 3

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Salma Abbas ^{1, 3, *}, EL Mehdi Hakkou ^{1, 3}, Mohammed Yassaad Oudrhiri ^{1, 3}, Adil Melhaoui ^{1, 3}, Nadia Cherradi ^{2, 3}, Hafsa El Ouazzani ^{2, 3} and Yasser ARKHA ^{1, 3}