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eISSN: 2582-8185 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in March 2026 (Volume 29, Issue 3) Submit manuscript

Evaluation of hepatic fibrosis in patients with chronic hepatitis B virus by non-invasive methods: Aspartate-to-platelet ratio index, Fibrosis-4, fibrotest and fibroscan

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  • Evaluation of hepatic fibrosis in patients with chronic hepatitis B virus by non-invasive methods: Aspartate-to-platelet ratio index, Fibrosis-4, fibrotest and fibroscan

Laté Mawuli Lawson-Ananissoh 1, *, Aklesso Bagny 1, Oumboma Bouglouga 2, Laconi Kaaga 1, Gad Namdiro 1, Rafiou El-Hadji Yakoubou 2, Lidawu Roland-Moise Kogoe 1 and Debehoma Venceslas Redah 1

1 Hepato-Gastroenterology unit, Campus Teaching Hospital, Lome-Togo.
2 Hepato-Gastroenterology unit, Kara Teaching Hospital, Kara-Togo.
 
Research Article
World Journal of Advanced Research and Reviews, 2022, 13(01), 172–179
Article DOI: 10.30574/wjarr.2022.13.1.0767
DOI url: https://doi.org/10.30574/wjarr.2022.13.1.0767
 
Received on 30 November 2021; revised on 04 January 2022; accepted on 06 January 2022
 
Background: The process of hepatic fibrosis is common to the various etiologies of chronic liver disease such as viral hepatitis B.
Objective: To evaluate hepatic fibrosis by non-invasive markers such as Aspartate-to-Platelet Ratio Index (APRI), fibrosis-4 (FIB-4), fibrotest and fibroscan.
Patients and Method: This was a descriptive study during a period of 32 months. Included in our study were the records of outpatients, chronic carriers of hepatitis B virus without viral co-infection C, D or HIV, followed in the Gastroenterology unit of the Campus Teaching Hospital of Lome-Togo.
Results: We retained 222 patients. Among the patients, 148 patients (66.67%) were classified in Phase 3 (inactive carrying). Only 10 patients (4.50%) had a APRI score indicating a fibrosis stage ≥ F4 (presence of cirrhosis). A FIB-4 score indicating the presence of cirrhosis was found in 12 patients (5.40%). The most represented stage at fibrotest was the F0 stage (45.45%). Cirrhosis was noted in 6.06% of cases at fibroscan. Patients with APRI score ≤ 2 (96.23%) had a FIB-4 score ≤ 3.25, (p = 0.0088).
Conclusion: The evaluation of hepatic fibrosis during chronic hepatopathies is essential for patients care because it influences therapeutic decisions.
 
Hepatic fibrosis; APRI; FIB-4; Fibrotest; Fibroscan; Togo
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2021-0767.pdf

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Laté Mawuli Lawson-Ananissoh, Aklesso Bagny, Oumboma Bouglouga, Laconi Kaaga, Gad Namdiro, Rafiou El-Hadji Yakoubou, Lidawu Roland-Moise Kogoe and Debehoma Venceslas Redah. Evaluation of hepatic fibrosis in patients with chronic hepatitis B virus by non-invasive methods: Aspartate-to-platelet ratio index, Fibrosis-4, fibrotest and fibroscan. World Journal of Advanced Research and Reviews, 2022, 13(1), 172-179. Article DOI: https://doi.org/10.30574/wjarr.2022.13.1.0767

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