1 Undergraduate Student, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
2 Department of Periodontology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
3 Department of Pediatric Dentistry, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
World Journal of Advanced Research and Reviews, 2025, 28(03), 1904-1909
Article DOI: 10.30574/wjarr.2025.28.3.4277
Received on 12 November 2025; revised on 25 December 2025; accepted on 27 December 2025
Background: Hepatitis C virus (HCV) infection affects 3% of the global population. The liver plays an important role in the balance of the immune system, so hepatitis C can cause disturbances in this system. These changes also manifest orally, making hepatitis C patients more susceptible to inflammatory diseases of the oral cavity, such as periodontitis.
Objective: This study was conducted to determine the pathogenesis of chronic hepatitis C, the pathogenesis of periodontitis, and the relationship between the pathogenesis of chronic hepatitis C and periodontitis.
Methods: This study was conducted using a literature review method with Google Scholar as the database.
Results: HCV infection causes a decline in the oral health of infected patients. Increased levels of IL-1α and IL-1β, which have significant implications in the pathogenic processes of periodontitis and chronic hepatitis C.
Conclusion: Chronic hepatitis C and periodontitis have a two-way relationship that influences each other. The inflammatory process is the key underlying the relationship between the two.
Inflammation; Hepatitis C; Periodontitis; Immune System
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Anastasia Hanania, Shonya Latifah, Eka Fitria Augustina, Lambang Bargowo, Tania Saskianti and Ardianti Maartrina Dewi. The Relationship Between Periodontitis and Hepatitis C. World Journal of Advanced Research and Reviews, 2025, 28(3), 1904-1909. Article DOI: https://doi.org/10.30574/wjarr.2025.28.3.4277