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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in March 2026 (Volume 29, Issue 3) Submit manuscript

The effect of Coenzyme Q10 on Periodontitis

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  • The effect of Coenzyme Q10 on Periodontitis

Anastasya Laila Definia Salsabila * and M. Daffa Refasyah Putra

Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.

Review Article

World Journal of Advanced Research and Reviews, 2025, 28(02), 1919-1924

Article DOI: 10.30574/wjarr.2025.28.2.3570

DOI url: https://doi.org/10.30574/wjarr.2025.28.2.3570

Received on 10 October 2025; revised on 19 November 2025; accepted on 21 November 2025

Background: Periodontitis is a chronic infectious disease that affects the supporting tissues of the teeth. Bacterial infection leads to inflammation of the periodontal tissues and gradually damages them through the inflammatory process. Coenzyme Q10 is an antioxidant agent that can suppress the inflammatory process in the periodontium. 

Purpose: This article was aimed to study the effect of Coenzyme Q10 on periodontitis. 

Review: Periodontitis is classified into chronic periodontitis and aggressive periodontitis. Chronic periodontitis commonly occurs in adults, while aggressive periodontitis develops in younger individuals with rapid bone loss. Local factors such as plaque and calculus play a role in the development of this disease. Early treatment is important to prevent tooth loss and negative impacts on general health. Coenzyme Q10 is an antioxidant compound that helps protect the body from oxidative damage. The effect of coenzyme Q10 on periodontitis has been proven by the reduction of PI, GI, BI, CAL, and PD as indicators of periodontitis. 

Conclusion: After comparing several articles discussing, the effects of coenzyme Q10 on periodontitis, it has been proven that coenzyme Q10, whether in the form of gel or oral supplements, is effective in treating periodontitis. This is evidenced by the decrease in the average values of clinical parameters such as PI, BI, GI, PD, and CAL after one week up to a maximum of three months of treatment. Coenzyme Q10 can work more effectively when its application is accompanied by scaling and root planing (SRP). Coenzyme Q10, as an antioxidant, has been proven to be very effective in treating periodontitis, both general periodontitis and chronic periodontitis. Additionally, coenzyme Q10 also works well and effectively in various patient conditions.

Periodontitis; Coenzyme Q10; Antioxidant; Reactive oxygen species; Periodontal therapy

https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2025-3570.pdf

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Anastasya Laila Definia Salsabila and M. Daffa Refasyah Putra. The effect of Coenzyme Q10 on Periodontitis. World Journal of Advanced Research and Reviews, 2025, 28(2), 1919-1924. Article DOI: https://doi.org/10.30574/wjarr.2025.28.2.3570

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