Potential of various groups of berries as antibiofilm agents against Streptococcus mutans, the cause of dental caries

Background: Dental caries is a common oral disease caused by biofilm formation by Streptococcus mutans. This biofilm is difficult to treat with conventional medication due to the protection of the extracellular matrix that envelops the bacteria. Therefore, an effective and safe antibiofilm agent is needed as an alternative for the prevention and treatment of caries. Berries are known to contain bioactive compounds such as polyphenols, flavonoids, and tannins that have antibacterial and antibiofilm potential. 

Purpose:  Examine the potential of various groups of berries as antibiofilm agents against Streptococcus mutans, the cause of dental caries. 

Methods: The reviewed studies include in vitro research on the antibiofilm activity of berry extracts and their bioactive compounds, as well as the molecular mechanism of action, which involves inhibiting bacterial adhesion, reducing the expression of virulence genes, and disrupting biofilm structure. 

Result: Berries are significantly able to inhibit the formation of S. mutans biofilm, thus having the potential to be used as an active ingredient in caries prevention products such as toothpaste and mouthwash. 

Conclusion: Berries are a promising natural alternative for the control of dental caries through an antibiofilm mechanism, thereby contributing to the sustainable improvement of oral health.